Peptides for skin, sleep and libido

• GHK-Cu 100 mg – Copper tripeptide (Gly-His-Lys) for research — 40,00 €
• PT-141 (Bremelanotide) 10 mg – Melanocortin receptor agonist — 39,00 €
• MT-2 (Melanotan 2 Acetate) 10 mg – Melanocortin receptor agonist — 35,00 €
• AHK-Cu 100 mg – Copper tripeptide (Ala-His-Lys) for research — 50,00 €
• MT-1 (Melanotan I) 10 mg – Afamelanotide analogue — 45,00 €
• Epithalon 50 mg – Synthetic tetrapeptide (AEDG) for research — 89,00 €
• DSIP 5 mg – Delta sleep-inducing peptide (neuropeptide) for research — 29,00 €

Peptides for skin, sleep and libido: the melanocortin system, circadian rhythms and skin regeneration

The Peptology category “Peptides for skin, sleep and libido” brings together molecules that act on three different regulatory systems: the melanocortin system (pigmentation and libido), the circadian system (sleep and pineal regulation) and the skin regeneration system (collagen, extracellular matrix, innate immunity).

All products are purchased online and shipped throughout Cyprus with fast delivery — lyophilised, with confirmed purity of over 99% (HPLC/MS) and an independent laboratory testing certificate (CoA) for each batch. General overview in the complete guide to the category.

The most popular products in the category

Three molecules cover the most frequently studied scenarios — one for each axis.

Comparison: the three melanocortin molecules

MT-1, MT-2 and PT-141 are structurally related and are often confused, yet they give different results. The difference lies solely in which receptor subtypes they activate.

Which peptide for which research model?

• Collagen and extracellular matrix: GHK-Cu is the standard in matrix remodelling models, while AHK-Cu is studied mainly in relation to the dermal papilla, the hair follicle and angiogenesis. Full comparison: GHK-Cu vs. AHK-Cu.
• Copper and antioxidant defence: GHK-Cu transports copper ions (Cu²⁺) in cell systems and in the literature is linked with the activity of antioxidant enzymes such as superoxide dismutase, as well as with broad changes in gene expression in fibroblasts. That is why it is also used in models of oxidative stress of the skin, not only in collagen models.
• Sleep architecture: DSIP is studied for its effect on the delta-wave phase, while melatonin is the start signal of the biological night itself.
• Long-term circadian regulation: epithalon acts at the level of the pineal gland itself and is studied over a longer horizon, not for a point effect on sleep. Details in the article Epithalon: telomerase and cellular renewal.
• Pigmentation vs. libido: MT-1 for models of pure melanogenesis, MT-2 for a broad melanocortin profile, PT-141 for central mechanisms of sexual behaviour. Comparison in the article MT-1 vs. MT-2.
• Melanogenesis and photobiology: MT-1 is a synthetic analogue of α-MSH ([Nle⁴, D-Phe⁷]-α-MSH) with increased stability against peptidases. It activates the MC1R receptor of melanocytes and is studied for eumelanin synthesis and the response of the epidermis in models of exposure to ultraviolet radiation.
• Central melanocortin pathways: MT-2 (a cyclic analogue of α-MSH) and the metabolite PT-141 are used in hypothalamic models, in which the MC3R and MC4R receptors of the paraventricular nucleus take part in the regulation of sexual behaviour and energy balance. PT-141 is chosen when the central action is needed without the strong pigmenting effect.
• Sleep and stress response: beyond delta waves, DSIP is studied in stress models, where changes in sleep are examined together with the daily variation of hormones of the hypothalamic–pituitary–adrenal axis. In this way it links the circadian axis of the category with stress regulation.
• Cellular ageing of the skin: in fibroblast cultures epithalon has been studied in relation to telomerase expression and the limit of cell divisions. It is the point of contact between the pineal sleep axis and the biology of skin ageing.
• Where to find the other molecules: the metabolic peptides MOTS-c, AICAR, SLU-PP-332, 5-Amino-1MQ, AOD-9604 and HGH Frag 176-191 are in the category Peptides for energy and regeneration, GHRP-2, GHRP-6, PEG-MGF and ACE-031 in Recovery and anabolic peptides, and LL-37 in Peptides for immunity and hormonal balance.

Product combinations from the category

The logic is the same everywhere: you combine molecules that act on different receptors or different levels of the same process. Molecules of the same receptor class simply compete with one another.

By contrast, MT-2 in combination with PT-141 offers no additional information: PT-141 is a metabolite of MT-2 and the two compete for the same receptors. The same applies to MT-1 with MT-2 in models of pure melanogenesis: both activate MC1R, so the effect of one covers the effect of the other. There MT-1 is enough, as it does not have the broad central action of MT-2.

Storage and safety rules

In lyophilised form the products are stored at 2–8 °C, protected from direct light and moisture. Copper tripeptides (GHK-Cu, AHK-Cu), melanotans (MT-1, MT-2) and melatonin are particularly light-sensitive — keep them in their original packaging and limit their exposure to light during handling.

• After reconstitution with Peptide Matrix Water™ — stable for up to 60 days at +2 °C to +8 °C.
• After reconstitution with bacteriostatic water — up to 28 days under the same conditions. Do not re-freeze a solution that has already been reconstituted. The differences between the solvents are analysed in this article.
• Direct the solvent slowly along the inner wall of the vial. Swirl gently, never shake — mechanical stress destroys the structure of the peptide.
• For an exact calculation of volume and concentration use the peptide calculator.
• Disinfect the rubber stopper with an alcohol swab before each withdrawal and note the date of the first puncture on the label.

Important note: The products in this category are intended exclusively for laboratory research and in vitro scientific analysis. They are not medicines, they are not approved preparations and they are not suitable for use in humans or animals. The mechanisms described come from the published scientific literature and are not a promise of results, a recommendation for use or a claim about the action of the research products offered.