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5-Amino-1MQ
5-Amino-1MQ 50 mg – NNMT inhibitor, small molecule
Peptology Ltd. · Peptides for energy and regeneration
5-Amino-1MQ is a NNMT inhibitor, small molecule that Peptology supplies strictly for laboratory research, in 50 mg. You can buy 5-Amino-1MQ in Cyprus online from €45.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
45,00 € · In stock
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 23/07/2026
What is 5-Amino-1MQ?
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule that acts as an inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase). It is studied mainly as a metabolic tool, with a close link to the metabolism of NAD⁺.
Note on accuracy: Unlike most products in the catalogue, 5-Amino-1MQ is not a peptide but a small molecule (an enzyme inhibitor). It is included here as a metabolic/NAD⁺-targeted research tool, alongside molecules such as NAD+.
NNMT “consumes” nicotinamide (a precursor of NAD⁺) and SAM. By inhibiting it, 5-Amino-1MQ preserves nicotinamide stores, supporting NAD⁺ levels, and activates the metabolism of fat cells. It is studied for fat reduction, metabolic health and NAD⁺-related pathways. See the range in the all products category.
In the Peptology version, it is supplied as a lyophilised research-grade powder with purity > 99%, in a 50 mg format. It is intended exclusively for scientific, research and in vitro applications — it is not a medicine or a supplement.
Available format: 50 mg
50 MG
High content
A large amount per vial, for extended metabolic protocols.
PURITY
> 99%
Validated per batch, for reliable and repeatable research results.
How 5-Amino-1MQ works — NNMT inhibition
NNMT INHIBITION
It inhibits the enzyme NNMT, which is elevated in adipose tissue — particularly in conditions of obesity and metabolic dysfunction.
PRESERVING NAD⁺/SAM
It preserves stores of nicotinamide (a precursor of NAD⁺) and SAM, supporting energy metabolism.
FAT METABOLISM
It activates the energy metabolism of fat cells, with studied reduction of fat storage.
Targeting the NAD⁺ “brake”
NNMT methylates nicotinamide, “pulling” a precursor away from the NAD⁺ salvage pathway. When NNMT is overactive (as in adipose tissue in obesity), this may negatively affect metabolism. 5-Amino-1MQ lifts this “drain”, favouring the preservation of NAD⁺.
So, while molecules such as NAD+ directly provide a precursor/coenzyme, 5-Amino-1MQ acts by protecting the endogenous stores from being consumed — a complementary strategy. The mechanisms come from preclinical studies.
Properties and pharmacology
- Class: small molecule — NNMT inhibitor; not a peptide
- Target: the enzyme NNMT (nicotinamide N-methyltransferase)
- Consequence: preservation of nicotinamide/NAD⁺ and SAM
- Studied actions: adipose tissue metabolism, fat reduction, metabolic health
- Connection: NAD⁺-targeted research tool
- Status: research molecule, not approved for clinical use
5-Amino-1MQ vs. NAD+ vs. MOTS-c
Comparison of three metabolic molecules related to NAD⁺ and energy metabolism. Reference data.
| 5-Amino-1MQ | NAD+ | MOTS-c | |
|---|---|---|---|
| Molecule type | Small molecule | Coenzyme | Peptide |
| Relationship with NAD⁺ | Protects stores | Provides directly | Indirect (AMPK) |
| Mechanism | NNMT inhibition | Enzyme cofactor | AMPK activation |
| Main focus | Adipose tissue / fat | Energy / ageing | Metabolic regulation |
| Status | Research | Research | Research |
Sources: literature on NNMT, NAD⁺ metabolism and adipose tissue.
Research
NNMT, fat and metabolism
Preclinical studies have shown that NNMT is elevated in adipose tissue in conditions of obesity and that inhibiting it (e.g. with 5-Amino-1MQ) can reduce fat cell size and fat storage, without reducing food intake in the models.
Link with NAD⁺
By keeping nicotinamide available for the NAD⁺ salvage pathway, 5-Amino-1MQ is also studied in the context of NAD⁺ homeostasis — a central field of metabolism and ageing research.
Data limitations
The data come mainly from preclinical studies; extensive clinical studies in humans are lacking. 5-Amino-1MQ remains a research molecule, not approved for clinical use.
Note: Scientific reference based on preclinical data. It is not medical advice or a claim for the product.
In brief — scientific profile
- Small molecule — NNMT inhibitor (not a peptide)
- Preserves nicotinamide/NAD⁺ and SAM — protects energy stores
- Activates fat cell metabolism — studied fat reduction
- Targets the NAD⁺ pathway — complementary to direct precursors
- 50 mg format — lyophilised powder, purity > 99%
- Research product — not approved for clinical use
Side effects and safety
The safety profile of 5-Amino-1MQ in humans is not fully characterised, as the data come mainly from preclinical studies. The reactions reported are generally mild.
Common
- Mild gastrointestinal discomfort
- Transient headache
- Fatigue
Less common
- Nausea
- Dizziness
- Transient metabolic fluctuations
Precautions
- Allergic reaction / hypersensitivity
- Effect on metabolic pathways (NAD⁺/SAM)
- Limited data in humans
Because it acts on central metabolic pathways (NAD⁺/SAM), any use must remain within the research context. Scientific reference, not instructions for use.
Related products
NAD+ 1000 mg
Direct NAD⁺ support
MOTS-c
Mitochondrial peptide (AMPK)
SS-31
Mitochondrial antioxidant
Peptide Matrix Water™
Recommended reconstitution solvent
See: All products · Blog
Research warning: 5-Amino-1MQ is offered exclusively for scientific, research and in vitro purposes. It is not intended for human/veterinary use, or for the diagnosis, treatment or prevention of any condition, and does not constitute medical advice.
Is 5-Amino-1MQ a peptide?
No. It is a small molecule that inhibits the enzyme NNMT. It is included in the catalogue as a metabolic/NAD⁺-targeted research tool, but it is not a peptide.
How does it differ from NAD+?
NAD+ directly provides the coenzyme/precursor; 5-Amino-1MQ protects the existing stores from being consumed via NNMT. They are complementary strategies.
Buy 5-Amino-1MQ in Cyprus – price
You can buy 5-Amino-1MQ in Cyprus online from Peptology. Prices by strength:
- 5-Amino-1MQ: €45.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
5-Amino-1MQ 50 mg: which strength
5-Amino-1MQ is available in: 50 mg.
Research protocols
Important: Reference information for research purposes — not a recommendation for use or medical advice.
In the research literature, 5-Amino-1MQ schedules are shaped around its metabolic character:
- As a small molecule, it is also studied with oral administration in preclinical models
- It is often studied in cycles, with metabolic markers (adipose tissue, NAD⁺) for monitoring
- It is being investigated in combination with NAD⁺ support strategies
It is sometimes studied together with NAD⁺ support molecules such as NAD+. The schedules come from the literature and do not constitute a recommendation for individual use.
Storage and reconstitution
It is supplied as a lyophilised powder in a 50 mg vial. As a small molecule it is relatively stable at room temperature, away from light/humidity. For reconstitution, the recommended solvent is Peptide Matrix Water™, which extends the shelf life of the solution.
- Before reconstitution: room temperature, away from light/moisture; up to 24 months.
- With Peptide Matrix Water™ (recommended): refrigerator 2–8 °C up to 60 days — the best stability option.
- With bacteriostatic water or sterile water: refrigerator 2–8 °C up to 28 days. No re-freezing.
- Reconstitution: add the solvent slowly down the wall, without vigorous agitation.
Laboratory tip: Add Peptide Matrix Water™ to your basket — the recommended stabilising solvent for all reconstituted products.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after addition (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 50 mg | 50 mg/mL | 25 mg/mL | 16.67 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
How is it stored?
Lyophilised at room temperature, away from light. After reconstitution: with Peptide Matrix Water™ — up to 60 days at 2–8 °C; with bacteriostatic water — up to 28 days.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
5-Amino-1MQ - 50 mg - Batch - 0226 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
-
Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about 5-Amino-1MQ
Where can I buy 5-Amino-1MQ in Cyprus and what does it cost?
In Cyprus you can buy 5-Amino-1MQ online from Peptology, from €45.00. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is 5-Amino-1MQ?
NNMT methylates nicotinamide → 1-MNA. Its inhibition preserves nicotinamide for salvage into NAD⁺ and modifies lipid metabolism.
In what form is 5-Amino-1MQ available?
As a lyophilised powder in a glass vial (50 mg). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of 5-Amino-1MQ?
The safety profile of 5-Amino-1MQ in humans is not fully characterised, as the data come mainly from preclinical studies. The reactions reported are generally mild.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.