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Peptides for immunity and hormonal balance
Peptides for immunity and hormonal balance
HCG (Human Chorionic Gonadotropin) 5000 IU – Glycoprotein hormone — 30,00 €
KPV 10 mg – Tripeptide (Lys-Pro-Val) derived from α-MSH — 39,00 €
Selank 5mg/10mg – Synthetic tuftsin analogue for research — 25,00 €
Kisspeptin-10 5 mg/10 mg – Peptide regulator of the hormonal axis (GnRH stimulator) — 30,00 €
Semax 5mg/10mg – ACTH(4-10) analogue neuropeptide for research — 30,00 €
Thymosin Alpha-1 5 mg / 10mg – Thymic peptide (thymalfasin) — 30,00 €
Thymulin 5mg/10mg – Zinc-dependent thymic nonapeptide for research — 30,00 €
Gonadorelin Acetate 2 mg – GnRH agonist for laboratory research — 35,00 €
Adamax 5 mg – Synthetic Semax analogue for research — 59,00 €
Vilon 20 mg – Bioregulatory dipeptide (Lys-Glu) for research — 40,00 €
LL-37 5 mg – Human cathelicidin (antimicrobial and immunomodulatory peptide) for wound, biofilm and innate immunity models — 60,00 €
Peptides for immunity and hormonal balance: the hypothalamic–pituitary axis, thymic peptides and neuroimmune regulation
The Peptology category “Peptides for immunity and hormonal balance” brings together molecules that act on three interconnected regulatory systems: the hypothalamic–pituitary–gonadal axis (kisspeptin, gonadorelin, HCG), thymic and immune regulation (thymosin alpha-1, thymulin, Vilon, KPV, LL-37) and the neuropeptide axis, which links the stress response with the immune response (Semax, Selank, Adamax).
All products are purchased online and shipped throughout Cyprus with fast delivery — lyophilised, with confirmed purity of over 99% (HPLC/MS) and an independent laboratory certificate (CoA) for each batch. More in the article Peptides: what they are, how they work and their safety profile.
The three axes of the category
THE HORMONAL AXIS (HPG)
Three successive levels of a single cascade: kisspeptin activates the hypothalamus, gonadorelin is the GnRH signal to the pituitary, and HCG acts directly on the gonads as an LH analogue.
THE THYMUS AND THE IMMUNE RESPONSE
Thymosin alpha-1 and thymulin are thymic hormones, studied for the maturation and differentiation of T lymphocytes. Vilon is a peptide bioregulator of the same school, KPV acts through an anti-inflammatory pathway, while LL-37 adds innate immunity.
THE NEUROIMMUNE AXIS
Semax, Adamax and Selank are synthetic neuropeptides in which cognitive and stress-related effects go hand in hand with measurable changes in immune markers — the classic model of the brain–immune link.
The most popular products in the category
Three molecules cover the most frequently studied scenarios — one for each axis.
The most-studied thymic peptide. A 28-amino-acid fragment of prothymosin alpha, with an extensive literature on dendritic cell activation, TLR2 and TLR9 signalling and T-lymphocyte maturation. The basic starting point in immunological models.
The neuropeptide with a dual profile. An analogue of the ACTH(4-10) fragment, without the hormonal action of the full peptide. Studied for its effect on BDNF and NGF, and for changes in immune markers in stress models.
GnRH itself. A synthetic decapeptide identical to the natural gonadotropin-releasing hormone. Studied for pulsatile stimulation of the pituitary and the resulting LH and FSH secretion — that is, it acts through the axis itself and not by bypassing it.
Comparison: the three levels of the hormonal axis
Kisspeptin-10, gonadorelin and HCG are often discussed together, yet they enter at three different points of the same cascade. This also determines what can be measured with each.
| Characteristic | Kisspeptin-10 | Gonadorelin | HCG 5000 IU |
|---|---|---|---|
| Level in the axis | Hypothalamus (highest) | Pituitary | Gonads (lowest) |
| Receptor | KISS1R (GPR54) | GnRH receptor | LH receptor |
| Depends on the pituitary | Yes | Yes | No — it bypasses it |
| Signal profile | Short, sequential | Short, pulsatile (minutes) | Prolonged (hours) |
| Typical choice for | Upstream regulation models | Evaluation of the pituitary response | Direct gonadal stimulation |
Which peptide for which research model?
- Highest level of the HPG axis: kisspeptin-10 acts through KISS1R on the GnRH neurons themselves — the molecule for models that study the regulation of the chain rather than its final result.
- Pituitary response: gonadorelin is identical to natural GnRH and has a very short half-life — which is exactly why it is the classic tool for evaluating the pulsatile response of the pituitary.
- Direct gonadal stimulation: HCG is a glycoprotein that binds to the same receptor as LH and bypasses the two upper levels — the signal is prolonged, but the upstream axis remains unexamined.
- T-lymphocyte maturation: thymosin alpha-1 is the most-studied thymic peptide — dendritic cells, TLR signalling, Th1 profile. Thymulin is a special case: its action is zinc-dependent, and without a bound zinc ion the molecule is inactive.
- Peptide bioregulators: Vilon is the dipeptide Lys-Glu from the science of peptide bioregulators — studied for its effect on gene expression in models of thymic and lymphoid cells, that is, at a completely different level from hormonal peptides.
- Control of inflammation: KPV is the C-terminal tripeptide of α-MSH (Lys-Pro-Val) — it retains the anti-inflammatory part of the action of α-MSH without the melanocortin effects. It is studied mainly in relation to NF-κB and the intestinal barrier.
- Innate immunity and antimicrobial peptides: LL-37 is the only human cathelicidin — an amphipathic peptide of 37 amino acids with a dual role: it interacts with bacterial membranes in models of antimicrobial action and regulates the inflammatory response (chemotaxis, TLR signalling). It is also studied in skin biology, as part of the first line of defence.
- Neurotrophic and cognitive models: Semax is the standard in BDNF/NGF models, while Adamax is a more recent modification of the same family with a different stability profile.
- Anxiety and the neuroimmune link: Selank is a tuftsin analogue — an immunopeptide whose anxiolytic effects in models are accompanied by measurable changes in the cytokine profile, including IL-6.
Product combinations from the category
The logic is the same everywhere: you combine molecules that act on different receptors or different levels of the same process. Molecules of the same receptor class simply compete with one another.
THE THYMIC PAIR
Thymosin alpha-1 + thymulin — both of thymic origin, but with different mechanisms of action: one through TLRs and dendritic cells, the other zinc-dependently, on the differentiation of T lymphocytes.
THE NEUROPEPTIDE PAIR
Semax + Selank — the classic pair: one with an activating profile, the other calming, derived from different parent molecules (an ACTH fragment and tuftsin).
THE CASCADE PAIR
Kisspeptin-10 + gonadorelin — two successive levels of the same axis. It allows the hypothalamic component of the response to be separated from the pituitary one.
INNATE + ACQUIRED IMMUNITY
LL-37 + thymosin alpha-1 — one at the first level of defence, the other at the maturation of T lymphocytes: two arms of the immune response with no mechanistic overlap.
+ SOLVENT
Every peptide needs a suitable reconstitution medium. See the category Solutions for peptides.
By contrast, Semax together with Adamax adds no additional information: both derive from the same ACTH fragment and compete for the same targets. Likewise, gonadorelin and HCG combined make the model impossible to interpret — HCG bypasses the pituitary and masks exactly the signal that gonadorelin is meant to measure.
Storage and safety rules
In lyophilised form the products are stored at 2–8 °C, protected from direct light and moisture. Glycoproteins (HCG) and larger peptide chains such as thymosin alpha-1 are more sensitive to temperature fluctuations than small peptides — for these, refrigeration is recommended immediately after reconstitution, avoiding repeated warming cycles.
- After reconstitution with Peptide Matrix Water™ — stable for up to 60 days at +2 °C to +8 °C.
- After reconstitution with bacteriostatic water — up to 28 days under the same conditions. Do not re-freeze a solution that has already been reconstituted. The differences between the solvents are analysed in this article.
- Direct the solvent slowly along the inner wall of the vial. Swirl gently, never shake vigorously — mechanical stress destroys the peptide structure, and with glycoproteins such as HCG the risk is even greater.
- For an exact calculation of volume and concentration use the peptide calculator.
- Disinfect the rubber stopper with an alcohol gauze pad before each withdrawal and note the date of the first puncture on the label.
Important notice: The products in this category are intended exclusively for laboratory research and in vitro scientific analysis. They are not medicines, they are not approved preparations and they are not suitable for use in humans or animals. The mechanisms described come from the scientific literature and are not a promise of results, a recommendation for use or a claim about the action of the research products offered.