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HCG
HCG 5000 IU – chorionic gonadotropin, a glycoprotein hormone
Peptology Ltd. · Peptides for immunity and hormonal balance
HCG is a chorionic gonadotropin, a glycoprotein hormone that Peptology supplies strictly for laboratory research, in 5000 IU. You can buy HCG in Cyprus online from €30.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
30,00 € · In stock
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 02/10/2026
What is HCG?
HCG (human chorionic gonadotropin) is a glycoprotein hormone that acts as an analogue of luteinising hormone (LH). It binds with high affinity to the LH/HCG receptor (LHCGR) and triggers the same pathways as natural LH — which is why it is used in research on the hypothalamic-pituitary-gonadal (HPG) axis, fertility and testosterone production.
Unlike molecules that act upstream in the HPG axis — such as Kisspeptin-10 (in the hypothalamus) or Gonadorelin (in the pituitary) — HCG acts directly on the gonads, stimulating the Leydig cells of the testis to produce testosterone.
It is studied in research for steroidogenesis (testosterone production), the maintenance of testicular function and spermatogenesis and the HPG axis. See the range in the all peptides category.
In the Peptology version, HCG is supplied as a lyophilised powder for research use in a 5000 IU format, with a batch certificate. It is intended exclusively for scientific, research and in vitro applications — it is not a medicine and is not approved for human/veterinary use.
Available form: 5000 IU
5000 IU
Typical form
Covers an extended research series at doses in the order of hundreds of international units (IU).
BATCH CERTIFICATE
Verified quality
Every batch has independent laboratory analysis.
How HCG acts — an LH analogue
LH/HCG RECEPTOR
HCG binds with high affinity to the LHCGR receptor (G-protein-coupled) on Leydig cells, mimicking the action of luteinising hormone.
cAMP / PKA
Activation increases intracellular cAMP and PKA, triggering steroidogenesis through the StAR protein and the enzymes CYP11A1 and CYP17A1.
INTRATESTICULAR TESTOSTERONE
The result is testosterone production in the testis, where the concentration is 50–100× higher than in the blood — critical for spermatogenesis.
Why HCG maintains testicular function
The testosterone concentration inside the testis is 50–100 times higher than in the blood, and this gradient is essential for the development of sperm. Clinical studies (Fertility and Sterility, The Journal of Urology) show that HCG, as an adjunctive therapy, can maintain sperm count in men receiving exogenous testosterone — which otherwise suppresses LH production.
Recent research notes that, unlike LH (which also activates survival/proliferation signals), HCG mainly triggers steroidogenic signals. The mechanisms come from studies and are not a guarantee of the result of a research product.
Properties and pharmacology
- Molecule type: glycoprotein hormone (α and β subunits)
- Target: the LH/HCG receptor (LHCGR), G-protein-coupled
- Signalling pathway: Gs → cAMP → PKA → StAR, CYP11A1, CYP17A1
- Main action: steroidogenesis — testosterone production in Leydig cells
- Particularity: a longer half-life than LH (due to glycosylation)
- Status: a research hormone in this context; prohibited in sport for men (WADA)
HCG vs. Gonadorelin vs. Kisspeptin-10 — level of action in the HPG axis
A comparison of three molecules that affect the HPG axis, at different levels — from the hypothalamus to the gonads. Reference data.
| HCG | Gonadorelin | Kisspeptin-10 | |
|---|---|---|---|
| Level of action | Gonads (testes) | Pituitary | Hypothalamus |
| Target | LH/HCG receptor | GnRH receptor | KISS1R receptor |
| Direct effect | Testosterone production | LH/FSH release | GnRH release |
| Molecule type | Glycoprotein | Decapeptide | Decapeptide |
| Status | Research (WADA-prohibited) | Research | Research |
Sources: literature on LH and HCG (Endocrine Reviews), studies of Leydig cells and male fertility.
Clinical studies
Maintenance of spermatogenesis
Studies show that HCG, as an adjunctive therapy, can maintain sperm production in men receiving exogenous testosterone — by maintaining intratesticular testosterone, which exogenous testosterone suppresses.
Hypogonadism and fertility
HCG is studied in hypogonadotropic hypogonadism and in various approaches to optimising male fertility, including non-obstructive azoospermia (andrology literature).
Dose and safety of Leydig cells
Recent research notes that exposure to high doses of HCG can cause endoplasmic reticulum stress and apoptosis in Leydig cells — a finding that draws attention to appropriate dose and duration ranges.
Note: Scientific reference based on published clinical results. It is not medical advice or a claim about the product.
In brief — scientific profile
- Glycoprotein hormone, LH analogue — binds the LH/HCG receptor
- Stimulates Leydig cells — testosterone production via cAMP/PKA
- Maintains intratesticular testosterone — a gradient critical for spermatogenesis
- Acts at the level of the gonads — downstream of Gonadorelin and Kisspeptin
- 5000 IU form — with a batch certificate
- Research product — not approved; prohibited for men in sport (WADA)
Side effects and safety
The safety profile of HCG is well characterised from clinical use. Many reactions are local or related to the rise in testosterone and oestrogen.
Common
- Injection-site reactions
- Headache
- Mood changes
Less common
- Gynaecomastia (raised oestrogen)
- Fluid retention
- Acne
Precautions
- Allergic reaction / hypersensitivity
- Leydig apoptosis at high, prolonged doses
- Aromatisation → raised oestrogen
Part of the testosterone produced under HCG is converted (aromatised) into oestrogens, which explains some of the effects. Scientific reference, not instructions for use.
Related peptides
Kisspeptin-10
Regulator in the hypothalamus
PT-141 (Bremelanotide)
Peptide for libido
Peptide Matrix Water™
Recommended reconstitution solvent
Bacteriostatic water
Typical reconstitution solvent
See: All peptides · Blog
Research warning: HCG is offered exclusively for scientific, research and in vitro purposes. It is not intended for human/veterinary use, or for the diagnosis, treatment or prevention of any condition, and is not medical advice. HCG is prohibited in sporting competitions (for men) by WADA.
How does it differ from Gonadorelin and Kisspeptin-10?
They act at different levels of the HPG axis: Kisspeptin-10 in the hypothalamus, Gonadorelin in the pituitary, and HCG directly on the gonads. HCG is the only one that directly stimulates testosterone production.
Buy HCG in Cyprus – price
You can buy HCG in Cyprus online from Peptology. Prices by strength:
- HCG: €30.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
HCG 5000 IU: which strength
HCG is available in: 5000 IU.
Research protocols
Important: Reference information from the clinical literature — not a recommendation for use or medical advice. HCG is not approved for human use in this context.
In the clinical literature, HCG was administered subcutaneously, at relatively small doses and moderate frequency:
- The usual protocols describe 500–1000 IU subcutaneously, 2–3 times a week
- This dose maintains testicular function without an excessive rise in serum testosterone
- High, prolonged doses are avoided because of the stress on Leydig cells
A reconstituted 5000 IU vial covers many administrations at these doses. The schedules come from the research literature and are not a recommendation for individual use.
Storage and reconstitution
HCG is supplied as a lyophilised powder in a 5000 IU vial. In lyophilised form it is stable, away from light/moisture. After reconstitution, HCG must be stored in the refrigerator; for reconstitution, the recommended solvent is Peptide Matrix Water™ (alternatively, bacteriostatic water), which extends the shelf life of the solution.
- Before reconstitution: preferably in the refrigerator; away from light/moisture.
- With Peptide Matrix Water™ (recommended): refrigerator 2–8 °C up to 60 days — the best stability option.
- With bacteriostatic water: refrigerator 2–8 °C, usually for up to ~28–30 days. Do not re-freeze.
- Reconstitution: add the solvent slowly down the wall, without vigorous agitation.
Laboratory tip: Add Peptide Matrix Water™ to your basket — the recommended stabilising solvent for all reconstituted peptides.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
How is it stored?
The lyophilised vial is preferably stored in the refrigerator, away from light. After reconstitution: with Peptide Matrix Water™ — up to 60 days at 2–8 °C; with bacteriostatic water — ~28–30 days.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
HCG - 5000 IU - Batch - 0226 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
- Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about HCG
Where can I buy HCG in Cyprus and what does it cost?
In Cyprus you can buy HCG online from Peptology, from €30.00. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is HCG?
It acts as an LH analogue: it binds to the LH/HCG receptor on the Leydig cells of the testis and stimulates testosterone production, maintaining the intratesticular level that spermatogenesis needs.
In what form is HCG available?
As a lyophilised powder in a glass vial (5000 IU). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of HCG?
The safety profile of HCG is well characterised from clinical use. Many reactions are local or related to the rise in testosterone and oestrogen.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.