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PT-141
PT-141 10 mg – synthetic α-MSH analogue
Peptology Ltd. · Peptides for skin, sleep and libido
PT-141 is a synthetic α-MSH analogue, melanocortin receptor agonist that Peptology supplies strictly for laboratory research, in 10 mg. You can buy PT-141 in Cyprus online from €39.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
39,00 € · In stock
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0126 |
Last updated: 18/10/2026
What is PT-141?
PT-141 (Bremelanotide) is a peptide agonist of the melanocortin receptors, a derivative of Melanotan II. Unlike Melanotan II (which is mainly used for pigmentation), PT-141 acts selectively on the pathways of libido and sexual arousal, through the central nervous system — not through peripheral vascular mechanisms.
PT-141 is unique in that it acts on the brain (hypothalamus and limbic regions), stimulating sexual desire and arousal in a neurogenic way — a mechanism different from that of PDE5 inhibitors (which act on blood flow).
It has been studied clinically (Phase III) in hypoactive sexual desire disorder (HSDD) in premenopausal women. See the range in the all peptides category.
In the Peptology version, it is supplied as a lyophilised powder for research use with purity > 99%, in a 10 mg format. It is NOT an approved medicine — it is intended exclusively for scientific, research and in vitro applications.
Available form: 10 mg
10 MG
Typical form
Covers an extended research series at doses in the order of a few mg.
PURITY > 99%
Batch certificate
Independent laboratory analysis per batch.
How PT-141 acts — melanocortin receptors
MC4R / MC3R RECEPTORS
It selectively activates the melanocortin receptors MC4R and MC3R in the hypothalamus and limbic regions — the centres of motivation and reward.
DOPAMINE RELEASE
It promotes the release of neurotransmitters such as dopamine, which play a central role in desire and pleasure — a neurogenic, not a vascular, pathway.
CENTRAL ACTION
The action takes place in the central nervous system, not in the vessels — a fact that differentiates it from PDE5 inhibitors and makes it complementary.
Why “short half-life, prolonged action”
PT-141 has a half-life of approximately 2.7 hours, but the subjective effect lasts much longer. In clinical studies, the onset of arousal was measured at 45–90 minutes after administration, lasting 6–8 hours (occasionally up to 8–12). This suggests that the activation of melanocortin receptors in the brain produces effects that exceed the presence of the peptide in the blood.
The mechanisms come from clinical studies with the approved medicine and are not a guarantee of the result of a research product.
Properties and pharmacokinetics
- Molecule type: melanocortin agonist peptide (metabolite of Melanotan II)
- Targets: MC4R and MC3R (hypothalamus, limbic regions)
- Route of action: central (CNS), neurogenic — not vascular
- Half-life: approximately 2.7 hours (range 1.9–4.0)
- Onset / duration: onset 45–90 minutes; duration 6–8 hours (up to 8–12)
- Regulatory history: Phase III clinical studies in HSDD
PT-141 vs. Melanotan II vs. Kisspeptin-10
A comparison of three peptides related to pigmentation, libido or the hormonal axis. Reference data.
| PT-141 | Melanotan II | Kisspeptin-10 | |
|---|---|---|---|
| Main profile | Libido (central action) | Pigmentation + libido | HPG axis regulation |
| Targets | MC4R / MC3R | MC1R / MC3R / MC4R | KISS1R |
| Characteristic action | Sexual desire | Tanning (melanin) | GnRH/LH release |
| Status | Phase III clinical studies | Research | Research |
| Route of administration | Subcutaneous | Subcutaneous | Subcutaneous |
Sources: bremelanotide prescribing information, HSDD clinical studies and melanocortin agonist literature.
Clinical studies
Hypoactive sexual desire disorder (HSDD)
In Phase III clinical studies, bremelanotide improved sexual desire and reduced the associated distress in premenopausal women with HSDD.
A central, not vascular, mechanism
Unlike PDE5 inhibitors, PT-141 acts through MC4Rs in the brain — a fact that explains the effect on desire (not only on the physical response) and the research interest in both sexes.
Research directions
The role of MC4R in sexual desire continues to be studied, in contexts that go beyond the original approved indication.
Note: Scientific reference based on published clinical results with the approved medicine. It is not medical advice or a claim about the product.
In brief — scientific profile
- Melanocortin agonist MC4R/MC3R — a derivative of Melanotan II
- Central, neurogenic action — in the brain, not in the vessels
- Stimulates desire and arousal — through dopamine release
- Phase III clinical studies — for HSDD in premenopausal women
- Prolonged action — 6–8 hours, beyond the plasma half-life
- The research product is not an approved medicine
Side effects and safety
The safety profile of PT-141 is well characterised from clinical use. Many reactions are mild and transient.
Common
- Nausea (the most common)
- Flushing
- Injection-site reactions
Less common
- Headache
- Transient rise in blood pressure
- Hyperpigmentation (with repeated use)
Precautions
- Allergic reaction / hypersensitivity
- Precaution in uncontrolled hypertension / cardiovascular disease
- Hyperpigmentation at high, repeated doses
Nausea and the transient rise in blood pressure are the most relevant effects. Scientific reference, not instructions for use.
Related peptides
Melanotan II
Broad melanocortin agonist
MT-1 (Melanotan I)
Melanocortin (pigmentation)
Kisspeptin-10
HPG axis regulator
Peptide Matrix Water™
Recommended reconstitution solvent
See: All peptides · Blog
Research warning: PT-141 (Bremelanotide) is offered exclusively for scientific, research and in vitro purposes. It is not an approved medicine. It is not intended for human/veterinary use, or for the diagnosis, treatment or prevention of any condition, and is not medical advice.
How does it differ from Melanotan II?
PT-141 is a metabolite of Melanotan II , but without the strong pigmentation effect. PT-141 is more selective for libido, while Melanotan II is mainly used for tanning.
Molecule identity
| CAS number | 189691-06-3 |
|---|---|
| Molecular weight | 1025.2 g/mol |
| Molecular formula | C50H68N14O10 |
| Class | Melanocortin receptor agonist (α-MSH analogue) |
| Form | Lyophilised powder in a glass vial |
| Storage | Lyophilisate: 2–8 °C, dry and protected from light · after reconstitution: 2–8 °C |
Buy PT-141 in Cyprus – price
You can buy PT-141 in Cyprus online from Peptology. Prices by strength:
- PT-141: €39.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
PT-141 10 mg: which strength
PT-141 is available in: 10 mg.
Research protocols
Important: Reference information — not a recommendation for use or medical advice. Research-grade PT-141 is not an approved medicine.
In a clinical context, bremelanotide was administered subcutaneously, on demand:
- Subcutaneous administration, approximately 45 minutes before the targeted moment
- Onset appears in 45–90 minutes; the duration extends to 6–8 hours
- In the approved form, a maximum of one dose per 24 hours and a limited number per month is recommended
The schedules come from clinical use and are not a recommendation for individual use.
Storage and reconstitution
Supplied as a lyophilised powder in a 10 mg vial. Lyophilised, it is stable at room temperature, away from light/moisture. For reconstitution, the recommended solvent is Peptide Matrix Water™, which significantly extends the life of the solution.
- Before reconstitution: room temperature, away from light/moisture; up to 24 months.
- With Peptide Matrix Water™ (recommended): refrigerator 2–8 °C up to 60 days — the best stability option.
- With bacteriostatic water: refrigerator 2–8 °C for up to 28 days. Do not re-freeze.
- Reconstitution: add the solvent slowly down the wall, without vigorous agitation.
Laboratory tip: Add Peptide Matrix Water™ to your basket — the recommended stabilising solvent for all reconstituted peptides.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after addition (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 10 mg | 10 mg/mL | 5 mg/mL | 3.33 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
How is it stored?
The lyophilised vial is stored at room temperature, away from light. After reconstitution: with Peptide Matrix Water™ — up to 60 days at 2–8 °C; with bacteriostatic water — up to 28 days.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
PT-141 - 10 mg - Batch - 0126 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
-
Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about PT-141
Where can I buy PT-141 in Cyprus and what does it cost?
In Cyprus you can buy PT-141 online from Peptology, from €39.00. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is PT-141?
It is an agonist of the melanocortin receptors (MC4R/MC3R) that acts on the brain, stimulating sexual desire and arousal in a neurogenic way — not through blood flow.
In what form is PT-141 available?
As a lyophilised powder in a glass vial (10 mg). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of PT-141?
The safety profile of PT-141 is well characterised from clinical use. Many reactions are mild and transient.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.