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MT-1
Melanotan 1 10 mg – synthetic α-MSH analogue (afamelanotide)
Peptology Ltd. · Peptides for skin, sleep and libido
Melanotan 1 (MT-1) is a synthetic α-MSH analogue (afamelanotide) that Peptology supplies strictly for laboratory research, in 10 mg. You can buy Melanotan 1 in Cyprus online from €45.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
45,00 € · In stock
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 18/10/2026
What is Melanotan 1?
MT-1 (Melanotan I, Afamelanotide) is a linear peptide of 13 amino acids, an analogue of melanocyte-stimulating hormone (α-MSH). Unlike MT-2 (Melanotan II), which is less selective, MT-1 is more selective for the MC1R receptor — the pigmentation pathway — with smaller effects on libido and appetite.
MT-1 activates melanin production in the skin through the same pathway activated by α-MSH and UV exposure, but without radiation. Because of its selectivity, its side-effect profile is generally narrower than that of MT-2.
It has a strong regulatory history: as Afamelanotide, it is approved by the FDA and EMA for photoprotection in patients with erythropoietic protoporphyria (EPP). It is studied in research for melanogenesis (pigmentation), photoprotection and melanocortin signalling. See the range in the all peptides category.
In the Peptology version, it is supplied as a lyophilised powder for research use with purity > 99%, in a 10 mg format. It is NOT an approved medicine — it is intended exclusively for scientific, research and in vitro applications.
How MT-1 acts — selective for MC1R
MC1R — PIGMENTATION
It binds selectively to the MC1R receptor in the skin and activates melanin production — the same pathway as α-MSH and UV, without radiation.
SELECTIVITY
Being more selective for MC1R than MT-2, it has smaller effects on libido and appetite (which depend on MC3R/MC4R).
PHOTOPROTECTION
The melanin produced offers some protection from UV radiation — the basis for the approval as Afamelanotide.
Why MT-1 is “the selective version”
Natural α-MSH acts on MC1R. MT-1 reproduces this action with greater stability and high selectivity for pigmentation. Unlike MT-2 (which also activates MC3R/MC4R, with effects on libido/appetite), MT-1 remains focused on pigmentation — which is why it was developed as an approved photoprotection medicine.
The mechanisms come from studies and are not a guarantee of the result of a research product.
Properties and pharmacology
- Structure: linear peptide of 13 amino acids, α-MSH analogue ([Nle4-D-Phe7]-α-MSH)
- Target: selective for MC1R (pigmentation)
- Characteristic action: melanogenesis (melanin production)
- Selectivity: smaller effects on libido/appetite compared with MT-2
- Clinical name: Afamelanotide, implant for EPP
- Status: research product
MT-1 vs. MT-2 vs. PT-141
A comparison of the three melanocortin peptides in the catalogue. The same family, different selectivity and dominant action. Reference data.
| MT-1 | MT-2 | PT-141 | |
|---|---|---|---|
| Dominant action | Tanning (selective) | Tanning + libido | Libido (selective) |
| Selectivity | More selective for MC1R | Broad (MC1/3/4/5R) | MC4R / MC3R |
| Structure | Linear (13 aa) | Cyclic | Cyclic (MT-2 metabolite) |
| Appetite / libido | Minor effect | Marked | Libido (selective) |
| Status | Clinical studies | Research | Clinical studies |
Sources: literature on afamelanotide / Melanotan I and α-MSH analogues.
Clinical studies
Photoprotection in EPP (approval)
As Afamelanotide, MT-1 has been studied clinically in patients with erythropoietic protoporphyria (EPP), a rare disease of severe photosensitivity.
Melanogenesis and skin
Studies confirmed the ability of MT-1 to stimulate melanin production by a UV-independent mechanism — the basis of the interest in pigmentation and photoprotection.
Other directions
The selectivity for MC1R has made it a subject of study for other dermatological conditions related to pigmentation as well.
Note: Scientific reference based on published results with the approved medicine. It is not medical advice or a claim about the product.
In brief — scientific profile
- Linear α-MSH analogue (13 aa) — more selective than MT-2
- Selective for MC1R — focused on pigmentation
- Small effects on libido/appetite — unlike MT-2
- Clinical studies (EPP) — photoprotection in EPP
- UV-independent mechanism — melanin production without radiation
- The research product is not an approved medicine
Side effects and safety
Because of its selectivity, MT-1 generally has a narrower side-effect profile than MT-2. The reactions reported are generally mild.
Common
- Injection-site reactions
- Mild nausea
- Flushing
Less common
- Headache
- Darkening of moles / freckles
- Fatigue
Precautions
- Need for monitoring of moles (naevi)
- New or atypical pigmented lesions
- Allergic reaction / hypersensitivity
As with all melanocortin peptides, monitoring of moles and pigmentary changes is important. Scientific reference, not instructions for use.
Related peptides
MT-2 (Melanotan II)
Broad melanocortin
PT-141 (Bremelanotide)
Libido focus (MT-2 metabolite)
Kisspeptin-10
HPG axis regulator
Peptide Matrix Water™
Stabilising solvent
See: All peptides · Blog
Research warning: MT-1 (Melanotan I) is offered exclusively for scientific, research and in vitro purposes. It is not an approved medicine. It is not intended for human/veterinary use, or for the diagnosis, treatment or prevention of any condition, and is not medical advice.
How does it differ from MT-2?
MT-2 is less selective and also causes effects on libido/appetite (via MC3R/MC4R). MT-1 is more selective for pigmentation (MC1R), with a narrower profile.
Can it be combined with Melanotan II?
Not recommended – MT-1 has a different profile and is used on its own for research purposes.
Molecule identity
| CAS number | 75921-69-6 |
|---|---|
| Molecular weight | 1646.8 g/mol |
| Molecular formula | C78H111N21O19 |
| Class | Synthetic α-MSH analogue (afamelanotide) |
| Form | Lyophilised powder in a glass vial |
| Storage | Lyophilisate: 2–8 °C, dry and protected from light · after reconstitution: 2–8 °C |
Buy Melanotan 1 in Cyprus – price
You can buy Melanotan 1 in Cyprus online from Peptology. Prices by strength:
- Melanotan 1: €45.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
Melanotan 1 10 mg: which strength
Melanotan 1 is available in: 10 mg.
Available strength: 10 mg
10 MG
Typical form
Covers an extended research series at doses in the order of mg.
PURITY > 99%
Batch certificate
Independent laboratory analysis per batch.
Research protocols
Important: Reference information for research purposes — not a recommendation for use or medical advice. MT-1 in this form is not an approved medicine.
In the research literature, MT-1 was studied subcutaneously, at doses in the order of micrograms:
- Compared with MT-2, MT-1 generally needs larger doses for comparable pigmentation
- Doses are expressed in micrograms (mcg); gradual titration is preferred
- The clinically studied form is a slow-release implant — a different mechanism from the research powder
The schedules come from the research literature and do not constitute a recommendation for individual use.
Storage and reconstitution
Supplied as a lyophilised powder in a 10 mg vial. The lyophilised form is stable at room temperature, away from light/moisture. After reconstitution, Peptide Matrix Water™ extends the shelf life.
- Before reconstitution: room temperature, away from light/moisture; up to 24 months.
- With Peptide Matrix Water™: refrigerator 2–8 °C for up to 60 days.
- With bacteriostatic water: refrigerator 2–8 °C for up to 28 days. Do not re-freeze.
- Reconstitution: add the solvent slowly down the wall, without vigorous agitation.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after addition (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 10 mg | 10 mg/mL | 5 mg/mL | 3.33 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
How is it stored?
The lyophilised vial is stored at room temperature, away from light. After reconstitution: with Peptide Matrix Water™ — up to 60 days at 2–8 °C; with bacteriostatic water — up to 28 days.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
MT‑1 (Melanotan I) - 10mg - Batch - 0226 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
-
Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about Melanotan 1
Where can I buy Melanotan 1 in Cyprus and what does it cost?
In Cyprus you can buy Melanotan 1 online from Peptology, from €45.00. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is Melanotan 1 (MT-1)?
It is an analogue of α-MSH that binds selectively to the MC1R receptor in the skin and activates melanin production — pigmentation independent of UV exposure.
In what form is Melanotan 1 available?
As a lyophilised powder in a glass vial (10 mg). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of Melanotan 1?
Because of its selectivity, MT-1 generally has a narrower side-effect profile than MT-2. The reactions reported are generally mild.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.