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Gonadorelin
Gonadorelin 2 mg – synthetic GnRH (decapeptide)
Peptology Ltd. · Peptides for immunity and hormonal balance
Gonadorelin is a synthetic GnRH (decapeptide) that Peptology supplies strictly for laboratory research, in 2 mg. You can buy Gonadorelin in Cyprus online from €35.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
35,00 € · Out of stock
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 23/07/2026
What is Gonadorelin?
Gonadorelin (Gonadorelin, GnRH, LHRH) is the synthetic form of gonadotropin-releasing hormone — a decapeptide produced by the hypothalamus. It acts on the pituitary, stimulating the release of the two gonadotropins: LH (luteinising) and FSH (follicle-stimulating).
It sits in the middle of the hypothalamic-pituitary-gonadal (HPG) axis: higher up is Kisspeptin-10 (which triggers GnRH release), while further down are the gonads (stimulated by LH — an action mimicked by HCG). Gonadorelin is essentially the “pituitary switch” of the whole axis.
It is studied in research for the HPG axis, the release of LH and FSH, fertility and gonadal function. See the range in the all peptides category.
In the Peptology version, it is supplied as a lyophilised powder for research use with purity > 99%, in a 2 mg format. It is intended exclusively for scientific, research and in vitro applications — it is not a medicine and is not approved for human/veterinary use.
Available form: 2 mg
2 MG
Typical form
Covers an extended research series at microgram doses.
PURITY > 99%
Batch certificate
Independent laboratory analysis per batch.
How Gonadorelin acts — the GnRH receptor
GnRH RECEPTOR
Gonadorelin binds to the GnRH receptor in the anterior pituitary, triggering the release of LH and FSH into the circulation.
PULSATILE = STIMULATION
With pulsatile (intermittent) administration, it mimics the natural rhythm of GnRH and stimulates the production of gonadotropins — the physiological profile.
CONTINUOUS = SUPPRESSION
With continuous administration, GnRH receptors become desensitised — LH/FSH release decreases. This “paradox” is the key to understanding the molecule.
Why “pulsatile vs continuous” changes everything
The hypothalamus releases GnRH in pulses, not continuously. Gonadorelin at this pulsatile rhythm stimulates the pituitary. By contrast, continuous exposure desensitises the GnRH receptors and suppresses the release of gonadotropins — the principle used by long-acting GnRH agonists. That is why the mode of administration is just as important as the molecule itself.
The half-life of Gonadorelin is very short (a few minutes), which makes it suitable for pulsatile administration. The mechanisms come from studies and are not a guarantee of the result of a research product.
Properties and pharmacology
- Structure: decapeptide (synthetic GnRH / LHRH)
- Target: the GnRH receptor in the anterior pituitary
- Direct action: release of LH and FSH
- Dependence on the mode: pulsatile = stimulation; continuous = suppression
- Half-life: very short (a few minutes)
- Regulatory history: research product
Gonadorelin vs. Kisspeptin-10 vs. HCG — level of action in the HPG axis
A comparison of three molecules that affect the HPG axis, at different levels — from the hypothalamus to the gonads. Reference data.
| Gonadorelin | Kisspeptin-10 | HCG | |
|---|---|---|---|
| Level of action | Pituitary | Hypothalamus | Gonads (testes) |
| Target | GnRH receptor | KISS1R receptor | LH/HCG receptor |
| Direct effect | LH/FSH release | GnRH release | Testosterone production |
| Molecule type | Decapeptide (GnRH) | Decapeptide | Glycoprotein |
| Status | Research (historically approved) | Research | Research (WADA-prohibited) |
Sources: literature on GnRH / gonadorelin and the HPG axis.
Clinical studies
Pulsatile administration and fertility
Pulsatile administration of Gonadorelin has historically been used to induce ovulation or stimulate gonadal function in hypogonadotropic hypogonadism, mimicking the natural rhythm of GnRH.
Diagnostic test of the HPG axis
Gonadorelin has been used as a diagnostic test: the LH/FSH response after administration helps to assess pituitary function — a classic tool of endocrinology.
The stimulation/suppression principle
The difference between pulsatile (stimulation) and continuous (suppression) administration is the basis of an entire class of medicines — the GnRH agonists — and is a central subject of research.
Note: Scientific reference based on published data. It is not medical advice or a claim about the product.
In brief — scientific profile
- Synthetic form of GnRH — the natural decapeptide of the hypothalamus
- Stimulates the release of LH and FSH — at the level of the pituitary
- Pulsatile = stimulation, continuous = suppression — the mode of administration changes the result
- Centre of the HPG axis — below Kisspeptin, above the gonads
- Approval history — in a clinical context
- Research product — exclusively for scientific applications
Side effects and safety
Common
- Injection-site reactions
- Headache
- Mild abdominal discomfort
Less common
- Nausea
- Flushing
- Dizziness
Precautions
- Allergic reaction / hypersensitivity
- Opposite action (suppression) with continuous administration
- For in vitro / laboratory use only
Injection-site reactions are the most common. Scientific reference, not instructions for use.
Related peptides
Kisspeptin-10
Regulator in the hypothalamus (higher up)
PT-141 (Bremelanotide)
Peptide for libido
Peptide Matrix Water™
Stabilising solvent
Bacteriostatic water
Typical reconstitution solvent
See: All peptides · Blog
Research warning: Gonadorelin is offered exclusively for scientific, research and in vitro purposes. It is not intended for human/veterinary use, or for the diagnosis, treatment or prevention of any condition, and is not medical advice.
How does it differ from Kisspeptin-10 and HCG?
They act at different levels of the HPG axis: Kisspeptin-10 in the hypothalamus (triggers GnRH), Gonadorelin in the pituitary (releases LH/FSH), and HCG in the gonads (mimics LH).
Can it be combined with other peptides?
Yes, it is often used together with Kisspeptin, HMG or clomiphene in studies for the restoration of fertility and hormonal balance.
Buy Gonadorelin in Cyprus – price
You can buy Gonadorelin in Cyprus online from Peptology. Prices by strength:
- Gonadorelin: €35.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
Gonadorelin 2 mg: which strength
Gonadorelin is available in: 2 mg.
Research protocols
Important: Reference information from the clinical literature — not a recommendation for use or medical advice. Gonadorelin is not approved for human use in this context.
Because of the very short half-life, the mode of administration is critical:
- For stimulation, administration must be pulsatile (at intervals, mimicking the natural rhythm of GnRH)
- Continuous administration causes the opposite effect — suppression of LH/FSH release
- Doses are expressed in micrograms (mcg)
Gonadorelin is studied in the broader context of the HPG axis, together with molecules such as Kisspeptin-10. The schedules come from the research literature and are not a recommendation for individual use.
Storage and reconstitution
Supplied as a lyophilised powder in a 2 mg vial. The lyophilised form is stable, away from light/moisture. After reconstitution, Peptide Matrix Water™ extends the shelf life.
- Before reconstitution: room temperature or refrigerator, away from light/moisture; up to 24 months.
- With Peptide Matrix Water™: refrigerator 2–8 °C for up to 60 days.
- With bacteriostatic water: refrigerator 2–8 °C for up to 28 days. Do not re-freeze.
- Reconstitution: add the solvent slowly down the wall, without vigorous agitation.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after addition (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 2 mg | 2 mg/mL | 1 mg/mL | 0.67 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
How is it stored?
Away from light/moisture; for prolonged storage, in the refrigerator. After reconstitution: with Peptide Matrix Water™ — up to 60 days at 2–8 °C; with bacteriostatic water — up to 28 days.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
Gonadorelin - 2 mg - Batch - 0226 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
-
Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about Gonadorelin
Where can I buy Gonadorelin in Cyprus and what does it cost?
In Cyprus you can buy Gonadorelin online from Peptology, from €35.00. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is Gonadorelin?
It is the synthetic form of GnRH. It binds to the GnRH receptor in the pituitary and stimulates the release of LH and FSH — the two hormones that govern gonadal function.
In what form is Gonadorelin available?
As a lyophilised powder in a glass vial (2 mg). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of Gonadorelin?
Injection-site reactions are the most common. Scientific reference, not instructions for use.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.