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KPV
KPV 10 mg – tripeptide Lys-Pro-Val
Peptology Ltd. · Peptides for immunity and hormonal balance
KPV is a tripeptide Lys-Pro-Val from the C-terminus of α-MSH that Peptology supplies strictly for laboratory research, in 10 mg. You can buy KPV in Cyprus online from €39.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
39,00 € · In stock
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 18/10/2026
What is KPV?
KPV (Lysine-Proline-Valine, Lys-Pro-Val) is a tripeptide — the C-terminal fragment of α-MSH (alpha melanocyte-stimulating hormone). It is one of the most studied anti-inflammatory peptides, with particular interest for the immune system and gut health.
Its distinctive characteristic is that it retains the anti-inflammatory action of α-MSH without the pigmentation actions, as it does not substantially activate the classic melanocortin receptors associated with skin colour.
It is studied in research for reduction of inflammation, regulation of the immune system, intestinal inflammation (colitis/IBD models) and healing. It works complementarily with regenerative/gut peptides such as BPC-157. See the range in the category all peptides.
In the Peptology version, it is supplied as a lyophilised research-grade powder with purity > 99%, in a 10 mg form. It is intended exclusively for scientific, research and in vitro applications — it is not a medicine or supplement.
Available form: 10 mg
10 MG
Typical research form
High-purity lyophilised powder with a laboratory certificate for each batch.
STRUCTURE
Lys-Pro-Val
Tripeptide — C-terminal fragment of α-MSH.
How KPV acts — regulation of inflammation
NF-κB INHIBITION
In preclinical models it inhibits the NF-κB pathway — the central “switch” of inflammation — reducing pro-inflammatory cytokines.
GUT HEALTH
Studied particularly in the gut: it reduces mucosal inflammation in colitis models, with the potential for local action.
NO PIGMENTATION
Retains the anti-inflammatory action of α-MSH without affecting skin pigment.
The anti-inflammatory “heart” of α-MSH
α-MSH has a dual role: pigmentation (via melanocortin) and anti-inflammatory action. KPV “isolates” the second: as the active C-terminal tripeptide, it retains the anti-inflammatory component without the effect on pigment — which is why it is an attractive tool in the study of inflammation.
Compared with regenerative gut peptides such as BPC-157 (which focuses on repair), KPV adds the component of immune regulation/anti-inflammatory action. The mechanisms come from preclinical studies.
Properties and pharmacology
- Structure: Lys-Pro-Val tripeptide — C-terminal fragment of α-MSH
- Main action: anti-inflammatory (inhibition of NF-κB and pro-inflammatory cytokines)
- Focus: immune regulation and intestinal inflammation (colitis models)
- Advantage: anti-inflammatory action without pigmentation
- Routes studied: systemic and local (e.g. intestinal)
- Status: research peptide, not approved for clinical use
KPV vs. BPC-157 vs. LL-37
Comparison of three peptides with action on inflammation, healing or gut/immunity. Reference data.
| KPV | BPC-157 | LL-37 | |
|---|---|---|---|
| Structure | Tripeptide (α-MSH fragment) | Peptide (15 aa) | Peptide (37 aa) |
| Main action | Anti-inflammatory | Repair/angiogenesis | Antimicrobial |
| Gut focus | Yes (main) | Yes | Indirect |
| Mechanism | NF-κB inhibition | Growth pathways | Membrane disruption |
| Status | Research | Research (WADA-prohibited) | Research |
Sources: literature on KPV/α-MSH and gut/anti-inflammatory peptides.
Research
Inflammation and gut health
Preclinical studies have shown that KPV reduces inflammation in colitis models by inhibiting pro-inflammatory pathways (such as NF-κB) in the intestinal mucosa — with the potential to act even at low concentrations.
Immune regulation and healing
Beyond the gut, it is studied for broader immune regulation and for accelerated healing in skin/inflammatory models — always retaining the “clean” profile without pigmentation.
Data limitations
The data come mainly from preclinical studies; extensive clinical studies in humans are lacking. KPV remains a research molecule, not approved for clinical use.
Note: Scientific reference based on preclinical data. It is not medical advice or a claim for the product.
In brief — scientific profile
- Tripeptide (C-terminal fragment of α-MSH) — the anti-inflammatory “heart”
- Inhibits inflammation — via NF-κB and pro-inflammatory cytokines
- Focus on gut health — colitis/IBD models
- No pigmentation — “clean” anti-inflammatory action
- 10 mg form — lyophilised powder of purity > 99%
- Research product — not approved for clinical use
Side effects and safety
KPV is generally considered well tolerated in the available data, with a “clean” profile (no pigmentation). The reactions reported are mostly mild.
Common
- Injection-site reactions
- Transient headache
- Mild gastrointestinal discomfort
Less common
- Dizziness
- Mild fatigue
- Transient irritation
Precautions
- Allergic reaction / hypersensitivity
- Effect on immune function
- Limited data in humans
As it acts on the inflammatory/immune response, any use must remain within the research context. Scientific reference, not an instruction for use.
Related peptides
BPC-157
Gut/regenerative peptide
LL-37
Antimicrobial/immunomodulatory
Thymosin Alpha-1
Immunostimulatory peptide
Peptide Matrix Water™
Recommended reconstitution solvent
See: All peptides · Blog
Research warning: KPV is offered exclusively for scientific, research and in vitro purposes. It is not intended for human/veterinary use, diagnosis, treatment or prevention of any condition and is not medical advice.
Molecule identity
| CAS number | 67727-97-3 |
|---|---|
| Molecular weight | 342.43 g/mol |
| Molecular formula | C16H30N4O4 |
| Class | Tripeptide Lys-Pro-Val (α-MSH fragment) |
| Form | Lyophilised powder in a glass vial |
| Storage | Lyophilisate: 2–8 °C, dry and protected from light · after reconstitution: 2–8 °C |
Buy KPV in Cyprus – price
You can buy KPV in Cyprus online from Peptology. Prices by strength:
- KPV: €39.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
KPV 10 mg: which strength
KPV is available in: 10 mg.
Research protocols
Important: Reference information for research purposes — not a recommendation for use or medical advice.
In the research literature, KPV regimens take into account its anti-inflammatory/gut character:
- For gut models, an oral/local approach (mucosal targeting) is also studied
- It is often studied in cycles, with inflammation markers as monitoring
- It is investigated in combination with gut regenerative peptides such as BPC-157
It is sometimes studied together with BPC-157 for complementary gut action. The regimens come from the literature and are not a recommendation for individual use.
Storage and reconstitution
Supplied as a lyophilised powder in a 10 mg vial. Lyophilised, it is stable at room temperature, away from light/moisture. For reconstitution, the recommended solvent is Peptide Matrix Water™, which significantly extends the life of the solution.
- Before reconstitution: room temperature, away from light/moisture; up to 24 months.
- With Peptide Matrix Water™ (recommended): refrigerator 2–8 °C up to 60 days — the best stability option.
- With bacteriostatic water or sterile water: refrigerator 2–8 °C up to 28 days. No re-freezing.
- Reconstitution: add the solvent slowly down the wall, without vigorous agitation.
Laboratory tip: Add Peptide Matrix Water™ to your basket — the recommended stabilising solvent for all reconstituted peptides.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after addition (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 10 mg | 10 mg/mL | 5 mg/mL | 3.33 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
How is it stored?
The lyophilised vial is stored at room temperature, away from light. After reconstitution: with Peptide Matrix Water™ — up to 60 days at 2–8 °C; with bacteriostatic water — up to 28 days.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
KPV - 10mg - Batch - 0226 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
- Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about KPV
Where can I buy KPV in Cyprus and what does it cost?
In Cyprus you can buy KPV online from Peptology, from €39.00. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is KPV?
It is a tripeptide (Lysine-Proline-Valine), the C-terminal fragment of α-MSH. It is studied as an anti-inflammatory peptide, particularly for gut health and immune regulation.
In what form is KPV available?
As a lyophilised powder in a glass vial (10 mg). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of KPV?
KPV is generally considered well tolerated in the available data, with a “clean” profile (no pigmentation). The reactions reported are mostly mild.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.