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ACE-031
ACE-031 1 mg – ActRIIB-Fc fusion protein
Peptology Ltd. · Recovery and anabolic peptides
ACE-031 is an ActRIIB-Fc fusion protein that binds myostatin that Peptology supplies strictly for laboratory research, in 1 mg. You can buy ACE-031 in Cyprus online from €40.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
40,00 € · In stock
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 02/10/2026
What is ACE-031?
ACE-031 (RAP-031, ActRIIB-Fc) is a recombinant fusion protein: it consists of the soluble portion of the activin receptor type IIB (ActRIIB) joined to the Fc portion of a human immunoglobulin. It works as a “ligand trap” — a decoy receptor that binds and “neutralises” molecules such as myostatin (GDF-8) and activin.
Note on accuracy: ACE-031 is not a small peptide but a larger fusion protein (ActRIIB-Fc). It is included here as a research molecule of the myostatin/activin pathway.
By binding myostatin before it reaches its natural receptor, ACE-031 lifts the “inhibition” that myostatin exerts on muscle growth — theoretically promoting an increase in muscle mass. It is also studied for its effect on bone metabolism. It works in a complementary way (through a different pathway) with anabolic molecules such as IGF-1 LR3. See the range in the all peptides category.
In the Peptology version, it is supplied as a lyophilised research-grade powder with purity > 99%, in a 1 mg format. It is intended exclusively for scientific, research and in vitro applications — it is not a medicine and is prohibited in sport (WADA).
Available format: 1 mg
1 MG
Typical research form
High-purity lyophilised powder with a laboratory certificate for each batch.
STRUCTURE
ActRIIB-Fc
Fusion protein: ActRIIB receptor + Fc portion.
How ACE-031 works — a myostatin “trap”
DECOY RECEPTOR
As a soluble ActRIIB, it binds myostatin and activin in the circulation, preventing them from reaching the real receptors.
LIFTING THE INHIBITION
Myostatin physiologically “brakes” muscle growth; neutralising it lifts this brake, allowing greater muscle mass.
BONE & METABOLISM
Through the ActRIIB pathway it is also studied for increased bone density and broader metabolic effects.
“Releasing the brake”, not direct stimulation
Unlike anabolic molecules that stimulate growth directly (e.g. IGF-1), ACE-031 acts by removing a natural inhibitory factor. Myostatin is a “negative regulator” of muscle mass — organisms with a natural deficiency of it show increased muscularity. ACE-031 reproduces this blockade pharmacologically.
Because the ActRIIB receptor binds many ligands (myostatin, activin, GDF-11 and others), its action is broad — something that also explains some of the side effects observed in clinical studies. The mechanisms come from clinical and preclinical studies.
Properties and pharmacology
- Class: recombinant fusion protein (ActRIIB-Fc) — “ligand trap”
- Targets: myostatin (GDF-8), activin, GDF-11 and other ActRIIB ligands
- Mechanism: blockade of the myostatin/activin pathway (lifting of inhibition)
- Studied actions: increase in muscle mass, bone density, metabolism
- Duration: the Fc portion prolongs the half-life compared with a small peptide
- Status: research molecule; prohibited in sport (WADA)
ACE-031 vs. Follistatin vs. IGF-1 LR3
Comparison of three approaches to muscle growth — two that block myostatin and one anabolic. Reference data.
| ACE-031 | Follistatin | IGF-1 LR3 | |
|---|---|---|---|
| Approach | Myostatin blockade | Myostatin blockade | Direct anabolic stimulation |
| Mechanism | Decoy receptor (ActRIIB) | Direct binding of myostatin | IGF-1 receptor |
| Structure | Fusion protein (Fc) | Protein | Peptide analogue |
| Bone | Yes (studied) | Indirectly | Indirectly |
| Status | Research (WADA-prohibited) | Research (WADA-prohibited) | Research (WADA-prohibited) |
Sources: literature on myostatin/ActRIIB inhibitors and anabolic molecules.
Research
Muscle mass and bone density
In preclinical and early clinical studies, ACE-031 increased muscle mass and showed an effect on markers of bone metabolism, through blockade of the myostatin/activin pathway. It was initially investigated in neuromuscular conditions.
Discontinuation of clinical development
The clinical development of ACE-031 was discontinued because of side effects attributed to its broad action on the ActRIIB receptor (e.g. vascular events such as nosebleeds and telangiectasias). This underlines that blocking multiple ligands is not without risks.
Data limitations
Given that clinical development stopped, the safety profile in humans is a significant limitation. ACE-031 remains strictly a research molecule and is prohibited by WADA.
Note: Scientific reference based on clinical/preclinical data. It is not medical advice or a claim for the product.
In brief — scientific profile
- ActRIIB-Fc fusion protein — decoy receptor (“ligand trap”)
- Binds myostatin/activin — lifts the natural inhibition of muscle growth
- Increase in muscle mass — through blockade, not direct stimulation
- Also studied for bone density — broad action on the ActRIIB pathway
- Clinical development stopped — due to side effects (vascular events)
- Research product — prohibited in sport (WADA)
Side effects and safety
ACE-031 has a more significant side-effect profile than simple peptides, because of its broad action on the ActRIIB receptor — a fact that led to the discontinuation of its clinical development.
Common
- Injection-site reactions
- Headache
- Fatigue
Reported clinically
- Nosebleeds
- Telangiectasias / gum bleeding
- Vascular events
Precautions
- Allergic reaction / hypersensitivity
- Clinical development discontinued for safety reasons
- Broad action on multiple ligands
The vascular events observed are attributed to the blockade of ligands beyond myostatin. This makes ACE-031 strictly a research molecule. Scientific reference, not instructions for use.
Related products
IGF-1 LR3
Anabolic IGF-1 analogue
HGH Frag 176-191
Lipolytic GH fragment
Somatropin (HGH)
Full growth hormone
Peptide Matrix Water™
Recommended reconstitution solvent
See: All products · Blog
Research warning: ACE-031 is offered exclusively for scientific, research and in vitro purposes. It is not intended for human/veterinary use, or for the diagnosis, treatment or prevention of any condition, and does not constitute medical advice. Its clinical development was discontinued for safety reasons and it is prohibited in sport (WADA).
Why did the DMD development stop?
Because of reports of epistaxis/telangiectasia and discussions with the regulatory authorities, the programme has been discontinued .
Is there a Phase III?
No – no Phase III studies have been published , and ACE-031 remains a subject of scientific interest mainly for research purposes .
Buy ACE-031 in Cyprus – price
You can buy ACE-031 in Cyprus online from Peptology. Prices by strength:
- ACE-031: €40.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
ACE-031 1 mg: which strength
ACE-031 is available in: 1 mg.
Research protocols
Important: Reference information for research purposes — not a recommendation for use or medical advice. The clinical development of ACE-031 was discontinued for safety reasons.
In the clinical/research literature, ACE-031 was studied in schedules of low frequency, because of the prolonged half-life provided by the Fc portion:
- Thanks to the Fc, it is studied with less frequent administration than a small peptide
- Markers of muscle mass/bone metabolism are used for monitoring
- Monitoring of vascular parameters is critical, given the side effects observed
The regimens come from the literature and are not a recommendation for individual use.
Storage and reconstitution
It is supplied as a lyophilised powder in a 1 mg vial. As a protein, it is heat-sensitive and is preferably stored refrigerated even when lyophilised. For reconstitution, the recommended solvent is Peptide Matrix Water™, which significantly extends the shelf life of the solution.
- Before reconstitution: preferably refrigerated at 2–8 °C, away from light; stable for an extended period.
- With Peptide Matrix Water™ (recommended): refrigerator 2–8 °C, the best option for solution stability.
- With bacteriostatic water: refrigerator 2–8 °C; use within a few weeks, no re-freezing.
- Reconstitution: add the solvent very slowly down the wall of the vial — the protein is sensitive to vigorous agitation.
Laboratory tip: Add Peptide Matrix Water™ to your basket — the recommended stabilising solvent for all reconstituted products.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after addition (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 1 mg | 1 mg/mL | 0.5 mg/mL | 0.33 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
How is it stored?
Preferably refrigerated even when lyophilised, away from light. After reconstitution: with Peptide Matrix Water™ — stable at 2–8 °C; as a protein it requires gentle handling.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
ACE-031 - 1mg - Batch - 0226 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
-
Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about ACE-031
Where can I buy ACE-031 in Cyprus and what does it cost?
In Cyprus you can buy ACE-031 online from Peptology, from €40.00. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is ACE-031?
It is a recombinant fusion protein (ActRIIB-Fc) that works as a “ligand trap”: it binds myostatin and activin, lifting the natural inhibition of muscle growth.
In what form is ACE-031 available?
As a lyophilised powder in a glass vial (1 mg). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of ACE-031?
ACE-031 has a more significant side-effect profile than simple peptides, because of its broad action on the ActRIIB receptor — a fact that led to the discontinuation of its clinical development.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.