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IGF-1 LR3
IGF-1 LR3 1/3 mg – modified 83-amino-acid IGF-1 analogue
Peptology Ltd. · Recovery and anabolic peptides
IGF-1 LR3 is a modified 83-amino-acid IGF-1 analogue that Peptology supplies strictly for laboratory research, in 1/3 mg. You can buy IGF-1 LR3 in Cyprus online from €60.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
60,00 € · In stock
- 1mg — 60,00 €
- 3mg — 129,00 €
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 02/10/2026
What is IGF-1 LR3?
IGF-1 LR3 (Long R3 IGF-1) is a modified analogue of human insulin-like growth factor 1 (IGF-1). Unlike natural IGF-1 (70 amino acids), it has 83 amino acids: arginine instead of glutamine at position 3 (hence “R3”) and a 13-amino-acid extension at the N-terminus (“Long”). These changes significantly reduce binding to the IGF binding proteins (IGFBPs), leaving more of the free, active form and a noticeably longer duration of action.
Most peptides of the GH axis — such as CJC-1295, GHRP-2 or Ipamorelin — act “high” in the cascade: they stimulate the pituitary to secrete GH, which indirectly increases IGF-1. IGF-1 LR3 acts at the end of the cascade — it is itself a growth factor and directly stimulates the IGF-1 receptor, bypassing the GH stage.
It is studied for hypertrophy and muscle regeneration, protein synthesis, cell proliferation and glucose metabolism. It is a research peptide — with no licence as a medicine in Cyprus or the EU. Because of its effect on glucose, it requires particular caution (see safety). See also the other recovery & anabolism peptides.
In the Peptology version, IGF-1 LR3 is supplied lyophilised with purity above 99% (HPLC/MS), with independent analysis (CoA per batch). It is available in three vial sizes — 0.1 mg, 1 mg and 3 mg.
Available pack sizes: 0.1 mg / 1 mg / 3 mg
0.1 MG
Micro pack
For precise small-volume in vitro runs and validation experiments with small quantities of peptide.
1 MG
Standard pack
The most common choice for repeated cell models and standard regeneration protocols.
3 MG
Extended pack
For larger research series and protocols with higher peptide consumption.
All three packs have the same purity > 99% and the same certificate per batch. The choice of size depends on the scale of the protocol, not on the concentration.
How it acts — direct activation of the IGF-1 receptor
IGF-1 RECEPTOR
It activates the IGF-1 receptor, initiating the PI3K/Akt (protein synthesis) and MAPK/ERK (proliferation) pathways.
REDUCED IGFBP BINDING
The Arg³ substitution reduces affinity for IGFBP-3 by ~100-fold — more free peptide and a half-life of ~20–30 hours.
HYPERTROPHY & SATELLITE CELLS
In research models it is associated with increased protein synthesis, nitrogen retention, satellite cell activation and possible hyperplasia.
The axis acts as a cascade: GHRH/GHRP → pituitary → GH → liver/tissues → IGF-1 → receptor. The GHRH analogues (CJC-1295, Sermorelin) and the GHRPs (GHRP-2, Ipamorelin) act at the start. IGF-1 LR3 acts at the end — an exogenous growth factor that directly stimulates the IGF-1 receptor, independently of GH. The data come from pharmacological studies and are not a claim about the research product.
Pharmacokinetics
- Biological half-life: ~20–30 hours (versus ~10–12 h for natural IGF-1)
- Biological activity: ~2–3× higher than natural IGF-1 in research models
- IGFBP binding: reduced ~100× (Arg³) — more of the free form
- Site of action: IGF-1 receptor (PI3K/Akt and MAPK/ERK pathways)
- Structure: 83 amino acids (Arg³ + 13-amino-acid extension at the N-terminus)
- Route in the protocols: subcutaneous or intramuscular
IGF-1 LR3 vs CJC-1295 vs GHRP-2
| IGF-1 LR3 | CJC-1295 | GHRP-2 | |
|---|---|---|---|
| Class | Growth factor (IGF-1 analogue) | GHRH analogue | Ghrelin mimetic |
| Site of action | IGF-1 receptor (effector) | GHRH receptor (pituitary) | GHS-R1a receptor |
| Position in the cascade | End (downstream of GH) | Start (upstream of GH) | Start (upstream of GH) |
| Half-life | ~20–30 h | ~30 min (without DAC) | ~30 min |
| Main research | Hypertrophy, regeneration, glucose | Pulsatile GH secretion | Strong GH pulse |
The values are indicative, from the literature. Scientific comparison table.
Profile at a glance
Side effects & safety
The most important safety issue is the effect on glucose. Because it increases glucose uptake and its action lasts 20–30 hours, the risk of hypoglycaemia is real in research models. The others are usually mild and dose-dependent.
Common
- Mild hypoglycaemia (hunger, tremor, sweating)
- Water retention
- Headache
- Tingling in the limbs
Less common
- Fatigue or drowsiness
- Irritability
- Local reactions at the injection site
- Transient joint pain
Particular caution
- Prolonged hypoglycaemia (long half-life)
- Growth factor — caution regarding cell proliferation
- Lack of long-term safety data
Related peptides
CJC-1295 without DAC
GHRH analogue
Ipamorelin
Selective GH secretagogue
GHRP-2
Ghrelin mimetic
CJC-1295 + Ipamorelin
Ready-made GH-axis blend
Somatropin (HGH)
Recombinant growth hormone
Peptide Matrix Water™
Reconstitution stabilising solution
Full catalogue: Recovery & anabolism peptides · Peptide solutions · Energy & regeneration peptides · Blog
Research warning: IGF-1 LR3 (Long R3 IGF-1) is offered exclusively for scientific research and in vitro purposes. It is not a medicine, has not been approved for use in humans or animals and does not replace medical advice. The information comes from pharmacological literature and preclinical data.
How does it differ from GH peptides such as CJC-1295?
GH peptides stimulate the pituitary to secrete GH, which indirectly increases IGF-1. IGF-1 LR3 is the growth factor itself — it acts at the end, directly on the IGF-1 receptor. That is why they are often combined.
Can I combine it with HGH or other peptides?
Yes, a common and effective combination is with HGH, CJC-1295 or PEG-MGF.
Buy IGF-1 LR3 in Cyprus – price
You can buy IGF-1 LR3 in Cyprus online from Peptology. Prices by strength:
- 1mg: €60.00
- 3mg: €129.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
IGF-1 LR3 1/3 mg: which strength
IGF-1 LR3 is available in: 1/3 mg.
Research protocols
Important: The following describes schedules from studies, for scientific and informative purposes — they are not a recommendation for use, medical advice or administration instructions. Because of the effect on glucose, glucose monitoring is required. Peptology's research-grade IGF-1 LR3 is not an approved medicine.
- Micro form (0.1 mg): for precise in vitro runs and small-volume models
- 1 mg / 3 mg forms: for larger regeneration and cell protocols
- Subcutaneous or intramuscular administration according to the protocol
- Glucose monitoring: recommended because of increased glucose uptake and the risk of hypoglycaemia
In protocols that map the GH–IGF-1 axis, it is combined with GHRH and GHRP analogues — e.g. CJC-1295 or Ipamorelin.
Storage & reconstitution
Supplied as a lyophilised powder in a vial. The lyophilised form is stable at room temperature, away from light and moisture — refrigeration before reconstitution is not mandatory. After reconstitution, stability depends on the solvent, with Peptide Matrix Water™ significantly extending the life of the peptide.
- Before: room temperature, original packaging, away from light/humidity.
- With Peptide Matrix Water™: in the refrigerator at +2 °C to +8 °C for up to 60 days — the stabilising formula extends the life compared with typical solvents.
- With bacteriostatic or sterile water: in the refrigerator +2 °C to +8 °C for up to 28 days. Do not refreeze.
- Volume: up to 3 mL of solvent. For an exact calculation use the peptide calculator — especially for small doses.
- Mixing: add slowly down the wall of the vial, without vigorous shaking. Gentle swirling.
Tip: Add Peptide Matrix Water™ to your basket — a stabilising solution for reconstituted research peptides. More in Bacteriostatic water vs acetic acid vs matrix water.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after addition (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 1 mg | 1 mg/mL | 0.5 mg/mL | 0.33 mg/mL |
| 3 mg | 3 mg/mL | 1.5 mg/mL | 1 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
Which pack should I choose — 0.1, 1 or 3 mg?
All three have the same purity > 99% and the same certificate. The 0.1 mg is for precise small-volume in vitro runs, the 1 mg is the standard form and the 3 mg is for larger protocols with higher consumption.
How is it stored and reconstituted?
The lyophilised vial at room temperature, away from light/humidity. After reconstitution: with Peptide Matrix Water™ for up to 60 days in the refrigerator +2 °C to +8 °C, with bacteriostatic/sterile water for up to 28 days. Do not refreeze.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
IGF-1 LR3 - 1mg - Batch - 0226 - Purity
IGF-1 LR3 - 3mg - Batch - 0226 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
-
Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about IGF-1 LR3
Where can I buy IGF-1 LR3 in Cyprus and what does it cost?
In Cyprus you can buy IGF-1 LR3 online from Peptology, from €60.00 (1mg: €60.00, 3mg: €129.00). Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is IGF-1 LR3?
An elongated analogue of human IGF-1 (83 amino acids) with arginine at position 3 and an extension at the N-terminus. It reduces IGFBP binding, giving a longer half-life (~20–30 h) and higher activity. It acts directly on the IGF-1 receptor.
In what form is IGF-1 LR3 available?
As a lyophilised powder in a glass vial (1/3 mg). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of IGF-1 LR3?
The most important safety issue is the effect on glucose. Because it increases glucose uptake and its action lasts 20–30 hours, the risk of hypoglycaemia is real in research models. The others are usually mild and dose-dependent.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.