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Sermorelin
Sermorelin 5 mg – GHRH (1-29) analogue
Peptology Ltd. · Recovery and anabolic peptides
Sermorelin is a GHRH (1-29) analogue that Peptology supplies strictly for laboratory research, in 5 mg. You can buy Sermorelin in Cyprus online from €39.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
39,00 € · In stock
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 18/10/2026
What is Sermorelin?
Sermorelin (GRF 1-29, GHRH 1-29) is a synthetic GHRH analogue — it corresponds to the first 29 amino acids of the natural growth hormone-releasing hormone. This segment is the minimum sequence that retains the full biological activity of the molecule, which is why Sermorelin is regarded as the “classic” GHRH analogue.
It acts by stimulating the pituitary to secrete growth hormone (GH) in a natural, pulsatile manner. It has a short duration of action, closely mimicking the physiological release of GH — unlike long-acting molecules such as CJC-1295 with DAC.
It is studied in research for stimulation of the GH/IGF-1 axis, body composition, sleep quality and as a diagnostic tool of pituitary function. It is often combined with GH-releasing peptides (GHRPs) such as Ipamorelin. See the range in the all peptides category.
In the Peptology version, it is supplied as a lyophilised research-grade powder with purity > 99%, in a 5 mg vial. It is intended exclusively for scientific, research and in vitro applications — it is not a medicine or a supplement and is prohibited in sport (WADA).
Available form: 5 mg
2 MG
Typical form
For validation experiments and protocols of usual size.
5 MG
Extended form
For longer courses and higher-consumption protocols.
The 5 mg vial has purity > 99% and a laboratory certificate per batch.
How Sermorelin works — the GHRH → GH → IGF-1 axis
GHRH RECEPTOR
As the 1-29 segment of GHRH, it binds to the pituitary GHRH receptors and stimulates growth hormone secretion.
GH PULSE
Because of its short action, it causes a physiological, pulsatile GH pulse — closely matching the natural secretion pattern.
IGF-1 INCREASE
The increased GH stimulates the liver to produce IGF-1, the main mediator of anabolic and metabolic actions.
The “most physiological” GHRH analogue
Because Sermorelin is the pure GHRH(1-29) sequence with a short half-life, it retains the physiological, pulsatile character of GH secretion and the negative-feedback mechanisms. It acts upstream on the axis (stimulating the pituitary), unlike administration of exogenous GH — a theoretical safety advantage.
In the classic “GHRH + GHRP” stack, Sermorelin provides the GHRH component and a GHRP (such as Ipamorelin) the complementary component, for a cumulative GH pulse. The mechanisms come from clinical and preclinical studies.
Properties and pharmacology
- Class: GHRH analogue — segment 1-29 (the minimum active sequence)
- Target: pituitary GHRH receptors
- Axis of action: GHRH → growth hormone (GH) → IGF-1
- Duration: short half-life — pulsatile, physiological GH secretion
- Use in stacks: complementary to a GHRP (Ipamorelin); diagnostic of pituitary function
- Status: research peptide; prohibited in sport (WADA)
Sermorelin vs. CJC-1295 (DAC) vs. Tesamorelin
Comparison of the main GHRH analogues studied for the GH/IGF-1 axis. Reference data.
| Sermorelin | CJC-1295 DAC | Tesamorelin | |
|---|---|---|---|
| Structure | GHRH 1-29 (pure) | GHRH analogue + DAC | Stabilised GHRH |
| Duration of action | Short (pulse) | Very prolonged | Moderate |
| Secretion profile | More physiological/pulsatile | Consistently high | Focus on visceral fat |
| Use in a GHRP stack | Yes (classic) | Yes | Less typical |
| Status | Research (WADA-prohibited) | Research (WADA-prohibited) | Research (WADA-prohibited) |
Sources: literature on GHRH analogues and Sermorelin (GRF 1-29).
Research
GH and IGF-1 stimulation
Sermorelin is historically one of the most studied GHRH analogues: it reliably stimulates GH secretion and the subsequent rise in IGF-1, while preserving the physiological feedback mechanism.
Diagnostic use
Because of its predictable response, Sermorelin was historically used as a diagnostic tool for assessing the GH secretory capacity of the pituitary.
Data limitations
Although there is a significant clinical background, this particular form is offered as a research product. Sermorelin is also prohibited by WADA.
Note: Scientific reference based on clinical/preclinical data. It is not medical advice or a claim for the product.
In brief — scientific profile
- GHRH analogue (segment 1-29) — the minimum fully active sequence
- Short, pulsatile GH stimulation — closely matching physiology
- Raises IGF-1 — via natural GH secretion
- Classic component of the GHRH + GHRP stack — with Ipamorelin
- One format — 5 mg vial
- Research product — prohibited in sport (WADA)
Side effects and safety
Sermorelin is generally considered well tolerated because of its physiological mechanism. The reactions reported are mostly mild and local.
Common
- Injection-site reactions
- Flushing / feeling of warmth
- Transient headache
Less common
- Fluid retention / oedema
- Arthralgia
- Dizziness / drowsiness
Precautions
- Allergic reaction / hypersensitivity
- Caution regarding the IGF-1 axis (proliferation)
- Caution regarding glucose intolerance
As with any molecule that raises IGF-1, there is a theoretical precaution in states of active malignancy. Scientific reference, not an instruction for use.
Related peptides
Ipamorelin
GHRP for the GHRH + GHRP stack
CJC-1295 without DAC
Short-acting GHRH analogue
Tesamorelin
GHRH analogue for visceral fat
Peptide Matrix Water™
Recommended reconstitution solvent
See: All peptides · Blog
Research warning: Sermorelin is offered exclusively for scientific, research and in vitro purposes. It is not intended for human/veterinary use, or for the diagnosis, treatment or prevention of any condition, and does not constitute medical advice. Sermorelin is prohibited in sport (WADA).
How does it differ from CJC-1295?
Both are GHRH analogues. Sermorelin has a short action (a more physiological pulse), while CJC-1295 with DAC has a much longer duration of action and consistently high levels.
Is it combined with Ipamorelin?
In research, Sermorelin (the GHRH component) is often studied together with a GHRP such as Ipamorelin , since the two stimuli act on different receptors and can cumulatively amplify the GH pulse.
Molecule identity
| CAS number | 86168-78-7 |
|---|---|
| Molecular weight | 3357.9 g/mol |
| Molecular formula | C149H246N44O42S |
| Class | GHRH analogue (1-29) |
| Form | Lyophilised powder in a glass vial |
| Storage | Lyophilisate: 2–8 °C, dry and protected from light · after reconstitution: 2–8 °C |
Buy Sermorelin in Cyprus – price
You can buy Sermorelin in Cyprus online from Peptology. Prices by strength:
- 5mg: €39.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
Sermorelin 5 mg: which strength
Sermorelin is available in: 5 mg.
Research protocols
Important: Reference information for research purposes — not a recommendation for use or medical advice.
In the research literature, Sermorelin schedules take into account its short duration of action and the physiology of GH:
- It is often studied with evening administration, to align with natural nocturnal GH secretion
- Because of the short half-life, it is studied on a daily schedule
- IGF-1 is often used as a marker of the axis response
It is often studied together with a GHRP, such as Ipamorelin. The schedules come from the literature and do not constitute a recommendation for individual use.
Storage and reconstitution
It is supplied as a lyophilised powder in a vial (2 or 5 mg). Lyophilised, it is stable at room temperature, away from light/humidity. For reconstitution, the recommended solvent is Peptide Matrix Water™, which significantly extends the shelf life of the solution.
- Before reconstitution: room temperature, away from light/moisture; up to 24 months.
- With Peptide Matrix Water™ (recommended): refrigerator 2–8 °C up to 60 days — the best stability option.
- With bacteriostatic water or sterile water: refrigerator 2–8 °C up to 28 days. No re-freezing.
- Reconstitution: add the solvent slowly down the wall, without vigorous agitation.
Laboratory tip: Add Peptide Matrix Water™ to your basket — the recommended stabilising solvent for all reconstituted peptides.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after addition (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 5 mg | 5 mg/mL | 2.5 mg/mL | 1.67 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
How is it stored?
The lyophilised vial is stored at room temperature, away from light. After reconstitution: with Peptide Matrix Water™ — up to 60 days at 2–8 °C; with bacteriostatic water — up to 28 days.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
Sermorelin - 5mg - Batch - 0226 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
-
Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about Sermorelin
Where can I buy Sermorelin in Cyprus and what does it cost?
In Cyprus you can buy Sermorelin online from Peptology, from €39.00. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is Sermorelin?
It is a GHRH analogue that corresponds to the first 29 amino acids of natural GHRH — the minimum fully active sequence. It stimulates the pituitary to secrete growth hormone in a pulsatile, physiological manner.
In what form is Sermorelin available?
As a lyophilised powder in a glass vial (5 mg). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of Sermorelin?
Sermorelin is generally considered well tolerated because of its physiological mechanism. The reactions reported are mostly mild and local.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.