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CJC-1295 without DAC
CJC-1295 5 mg – GHRH analogue without DAC (Mod GRF 1-29)
Peptology Ltd. · Recovery and anabolic peptides
CJC-1295 is a GHRH analogue without DAC (Mod GRF 1-29) that Peptology supplies strictly for laboratory research, in 5 mg. You can buy CJC-1295 in Cyprus online from €25.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
25,00 € · In stock
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 18/10/2026
What is CJC-1295?
CJC-1295 without DAC (also known as Modified GRF 1-29, Mod GRF 1-29) is a synthetic, short-acting GHRH analogue — of the hormone that releases growth hormone. It is a modified fragment of GRF (1-29) with four amino acid substitutions, which give it resistance to degradation by the peptidase DPP-4 and other plasma proteases, while retaining the short, physiological action profile.
The designation “without DAC” is critical. DAC (Drug Affinity Complex) is an albumin-binding group that, in the “with DAC” version, extends the half-life to days and maintains a steady, raised GH baseline. The version without DAC does not have this group — its half-life is ~30 minutes, producing short, pulsatile GH peaks that mimic more faithfully the natural secretion rhythm from the pituitary.
It acts on the GHRH receptor in the pituitary. This distinguishes it from the GHRP peptides / ghrelin mimetics (such as GHRP-2 or Hexarelin), which act on the separate GHS-R1a receptor. As these are two different pathways, in studies they are combined for a synergistic effect — hence the popularity of the combination with a GHRP / Ipamorelin. It is a research peptide with no approval as a medicine; it is studied in the GH/IGF-1 axis, regeneration, body composition and lipolysis.
At Peptology it is supplied as a lyophilised peptide with purity above 99% (HPLC/MS, CoA per batch), in a 5 mg pack. Exclusively for research and in vitro applications. See also the peptides for regeneration and anabolism.
Available pack: 5 mg
CJC-1295 without DAC is available in a lyophilised 5 mg form, covering the typical scales of research work — from individual in vitro runs to larger GH-axis protocols, including schedules in combination with GHRP peptides.
5 MG
Standard pack
A lyophilised GHRH analogue with purity > 99%, for studies of the GH/IGF-1 axis, regeneration and schedules in combination with GHRP.
COMBINATION
A ready-made blend of GHRH + GH secretagogue in one vial — for protocols that study the synergy of the two receptors.
The 5 mg pack has purity > 99% and a laboratory certificate for the specific batch. The choice of quantity depends on the scale of the protocol, not on the concentration of the active substance.
How it acts — stimulation of the GHRH axis
CJC-1295 without DAC stimulates the GHRH receptor in the pituitary and causes a short, pulsatile GH peak. The three axes below determine its profile.
GHRH RECEPTOR
It binds the GHRH receptor, activating GH synthesis and release via cAMP — GH peak usually within 15–30 minutes.
SHORT PROFILE (WITHOUT DAC)
The absence of an albumin-binding group (DAC) means a half-life of ~30 minutes — short, pulsatile GH peaks instead of a steady baseline.
SYNERGY WITH GHRP
The GHRH receptor acts in parallel with GHS-R1a (GHRP/ghrelin). The combination is associated with a 3–5-fold increase in GH release.
Without DAC vs with DAC — the difference
The version with DAC has an albumin-binding group that extends the half-life to days and maintains a steady, raised GH/IGF-1 baseline. The version without DAC (this product) acts briefly (~30 minutes) and causes isolated, physiological GH pulses. Because the GHRH and GHS-R1a (GHRP/ghrelin) pathways are independent, in protocols the GHRH analogue is combined with a secretagogue — e.g. GHRP-2, Hexarelin or Ipamorelin. Data from pharmacological studies, not a claim about the research-grade product.
Pharmacokinetics
- Half-life: ~30 minutes (absence of a DAC group)
- GH peak: usually 15–30 minutes after subcutaneous administration
- Action profile: short, pulsatile — mimics the natural GH rhythm
- Site of action: GHRH receptor in the pituitary (cAMP pathway)
- Enzymatic stability: 4 amino acid substitutions → resistance to DPP-4
- Schedule: subcutaneous, often in combination with a GHRP
CJC-1295 without DAC vs Sermorelin vs GHRP-2
Sermorelin is another GHRH analogue (same receptor), while GHRP-2 is a ghrelin mimetic at GHS-R1a. Scientific comparison data.
| CJC-1295 without DAC | Sermorelin | GHRP-2 | |
|---|---|---|---|
| Class | GHRH analogue (Mod GRF 1-29) | GHRH analogue (GRF 1-29) | Ghrelin mimetic (GHRP) |
| Receptor | GHRH-R | GHRH-R | GHS-R1a |
| Half-life | ~30 minutes | ~10–20 minutes | ~30 minutes |
| GH profile | Pulsatile, physiological | Pulsatile | Strong GH pulse |
| Role in the schedules | GHRH basis (with a GHRP) | GHRH basis | Partner secretagogue |
The pharmacokinetic values are approximate, from the pharmacological literature. Not a direct head-to-head comparison or a claim about a research-grade product.
Clinical and preclinical data
CJC-1295 is a research molecule — it has not gone through a phase III approval programme. Most controlled clinical data relate to the form with DAC: in early studies in healthy adults, a dose-dependent increase in GH and IGF-1 was documented after subcutaneous administration, with good tolerability. The form without DAC (Mod GRF 1-29) causes short GH peaks (15–30 minutes) that mimic the endogenous rhythm — a tool for studies of the pulsatility of the GH axis.
The combination with a GHRP secretagogue is associated with 3–5-fold higher GH release (separate receptors). The information is scientific and informative; it is not medical advice or a claim about the research-grade product.
Profile at a glance
- Short-acting GHRH analogue (Mod GRF 1-29) — pulsatile stimulation of the GH axis
- Half-life ~30 minutes due to the absence of a DAC group — GH peak in 15–30 minutes
- 3–5× synergy with GHRP (Ipamorelin, GHRP-2, Hexarelin) — two separate receptors
- Resistance to DPP-4 thanks to the four amino acid substitutions
Adverse effects and safety
Described as well tolerated, with mostly local and mild adverse effects, which are dose-dependent and reversible.
Common
- Redness/itching at the injection site
- Transient facial flushing
- Sensation of warmth after administration
- Mild headache
Less common
- Mild fatigue/drowsiness
- Water retention
- Tingling in the limbs
- Transient dizziness
To be considered
- Possible effect on glucose metabolism
- Hypersensitivity to the ingredients
- Lack of long-term safety data
Related peptides
CJC-1295 + Ipamorelin
Ready-made blend of GHRH + GH secretagogue
GHRP-2
Ghrelin mimetic (GHS-R1a)
Hexarelin
Potent GH secretagogue
Sermorelin
GHRH analogue (GRF 1-29)
Peptide Matrix Water™
Reconstitution stabilising solution
Catalogue: Peptides for regeneration and anabolism · Blog
Research warning: CJC-1295 without DAC (Mod GRF 1-29) is offered exclusively for scientific, research and in vitro purposes. It is not a medicine, is not approved for use in humans or animals and does not replace medical advice. All information comes from the pharmacological and research literature and is provided for scientific and informative purposes; it is not a claim about the action of the research-grade product offered by Peptology.
Is it combined with a GHRP?
Yes — a classic research schedule. CJC-1295 acts on GHRH-R and the GHRPs ( GHRP-2 , Hexarelin , Ipamorelin) on GHS-R1a, with 3–5× higher GH release. Ready-made: CJC-1295 + Ipamorelin .
How does it differ from Sermorelin?
Both are GHRH analogues at the same receptor, but CJC-1295 (Mod GRF 1-29) has four amino acid substitutions that increase resistance to DPP-4 — a slightly more stable profile than Sermorelin.
Molecule identity
| CAS number | 863288-34-0 |
|---|---|
| Molecular weight | 3367.9 g/mol |
| Molecular formula | C152H252N44O42 |
| Class | Short-acting GHRH analogue (Mod GRF 1-29) |
| Form | Lyophilised powder in a glass vial |
| Storage | Lyophilisate: 2–8 °C, dry and protected from light · after reconstitution: 2–8 °C |
Buy CJC-1295 in Cyprus – price
You can buy CJC-1295 in Cyprus online from Peptology. Prices by strength:
- CJC-1295: €25.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
CJC-1295 5 mg: which strength
CJC-1295 is available in: 5 mg.
Research protocols
Important: The information relates to studies, for scientific and informative purposes — not a recommendation for use or medical advice. Research-grade CJC-1295 without DAC is not an approved medicine.
- Administered subcutaneously, usually in combination with a GHRP (short half-life).
- Observations at a dose of ~10 µg/kg daily (up to 16 weeks) described a GH/IGF-1 increase consistent with the natural rhythm.
- Combination schedules: GHRH analogue + GHRP (Ipamorelin / GHRP-2 / Hexarelin). Ready-made blend: CJC-1295 + Ipamorelin.
Storage and reconstitution
- Before reconstitution: room temperature, protected from light/moisture; refrigeration is not mandatory.
- With Peptide Matrix Water™: in the refrigerator at +2 to +8 °C for up to 60 days.
- With bacteriostatic/sterile water: in the refrigerator at +2 to +8 °C for up to 28 days; do not re-freeze.
- Reconstitution: add the solvent slowly down the wall (max. 3 mL); swirl gently, do not shake.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after addition (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 5 mg | 5 mg/mL | 2.5 mg/mL | 1.67 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
How is it stored and reconstituted?
Lyophilised at room temperature. After reconstitution: with Peptide Matrix Water™ up to 60 days; with bacteriostatic/sterile water up to 28 days, without re-freezing.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
CJC‑1295 without DAC - 5mg - Batch - 0226 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
-
Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about CJC-1295
Where can I buy CJC-1295 in Cyprus and what does it cost?
In Cyprus you can buy CJC-1295 online from Peptology, from €25.00. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is CJC-1295?
A short-acting GHRH analogue (Mod GRF 1-29) that stimulates the GHRH receptor in the pituitary and causes pulsatile GH release, mimicking the natural rhythm.
In what form is CJC-1295 available?
As a lyophilised powder in a glass vial (5 mg). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of CJC-1295?
Described as well tolerated, with mostly local and mild adverse effects, which are dose-dependent and reversible.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.