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PEG-MGF
PEG-MGF 2 mg – pegylated MGF (IGF-1Ec) analogue
Peptology Ltd. · Recovery and anabolic peptides
PEG-MGF is a pegylated MGF (IGF-1Ec) analogue that Peptology supplies strictly for laboratory research, in 2 mg. You can buy PEG-MGF in Cyprus online from €40.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
40,00 € · In stock
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 02/10/2026
What is PEG-MGF?
PEG-MGF (Pegylated Mechano Growth Factor, IGF-1Ec) is a pegylated version of MGF — a natural splice variant of IGF-1 produced in muscle in response to mechanical stress and to the micro-damage caused by exercise. It is the “signal” that triggers the repair and growth of muscle tissue.
Its central role is the activation of satellite cells — the stem cells of muscle — so that they proliferate and contribute to the regeneration and hypertrophy of muscle fibres.
Pegylation (the addition of polyethylene glycol) is critical: natural MGF has an extremely short half-life (minutes), while pegylation significantly prolongs the duration of action, making it a practical research tool. It works complementarily with IGF-1 LR3. See the range in the category all peptides.
In the Peptology version, it is supplied as a lyophilised research-grade powder with purity > 99%, in a 2 mg form. It is intended exclusively for scientific, research and in vitro applications — it is not a medicine and is prohibited in sport (WADA).
Available form: 2 mg
2 MG
Typical research form
High-purity lyophilised powder with a laboratory certificate for each batch.
PEGYLATION
Prolonged action
Polyethylene glycol significantly extends the half-life compared with natural MGF.
How PEG-MGF acts — satellite cells
SATELLITE CELL ACTIVATION
Activates and promotes the proliferation of satellite cells — the stem cells that repair and “build” muscle.
MUSCLE REPAIR
As a mechanical-stress “signal”, it directs the repair of micro-damaged muscle fibres and hypertrophy.
PROLONGED ACTION
Pegylation extends the half-life from minutes to hours/days, keeping the signal active for longer.
A variant of IGF-1 with a “mechanical” role
MGF (IGF-1Ec) is an alternative form (splice variant) of the IGF-1 gene that is expressed specifically after mechanical load/injury of muscle. Unlike “systemic” IGF-1, the role of MGF is mainly local and “initiating”: it starts the regenerative response by activating satellite cells.
That is why it is often studied in synergy with IGF-1 LR3 (which gives a more prolonged, systemic anabolic action) — MGF “opens” regeneration and IGF-1 LR3 supports it. The mechanisms come from preclinical studies.
Properties and pharmacology
- Structure: pegylated MGF — a splice variant of IGF-1 (IGF-1Ec)
- Main action: activation and proliferation of satellite cells
- Role: local, “initiating” signal of muscle regeneration/hypertrophy
- Pegylation: significantly prolongs the (very short) natural half-life
- Synergy: with IGF-1 LR3 (systemic anabolic support)
- Status: research peptide; prohibited in sport (WADA)
PEG-MGF vs. IGF-1 LR3 vs. Somatropin
Comparison of three molecules of the GH/IGF-1 axis with a different role in muscle growth. Reference data.
| PEG-MGF | IGF-1 LR3 | Somatropin | |
|---|---|---|---|
| What it is | IGF-1 variant (Ec) | IGF-1 analogue (long-acting) | Full GH |
| Main role | Satellite cells | Systemic anabolic | Full range of GH |
| Action | Local / “initiating” | Prolonged / systemic | Systemic (GH→IGF-1) |
| Synergy | With IGF-1 LR3 | With PEG-MGF | Top of the axis |
| Status | Research (WADA-prohibited) | Research (WADA-prohibited) | Research (WADA-prohibited) |
Sources: literature on MGF (IGF-1Ec), IGF-1 analogues and the GH axis.
Research
Satellite cells and muscle regeneration
Preclinical studies have shown that MGF activates the proliferation of satellite cells and enhances muscle repair after injury — a fundamental role in the growth and renewal of muscle tissue.
The role of pegylation
Natural MGF is degraded within minutes. Pegylation extends its stability and action, making the results practically measurable in research protocols.
Data limitations
The data come mainly from preclinical studies; extensive clinical studies in humans are lacking. PEG-MGF remains a research molecule and is prohibited by WADA.
Note: Scientific reference based on preclinical data. It is not medical advice or a claim for the product.
In brief — scientific profile
- Pegylated MGF (IGF-1Ec) — a variant of IGF-1 with a “mechanical” role
- Activates satellite cells — stem cells of muscle
- Local, “initiating” signal — starts repair/hypertrophy
- Pegylation extends the half-life — from minutes to hours/days
- Synergy with IGF-1 LR3 — “initiating” + systemic support
- Research product — prohibited in sport (WADA)
Side effects and safety
The safety profile of PEG-MGF in humans is not fully characterised, as the data come mainly from preclinical studies. The reactions reported are generally mild.
Common
- Injection-site reactions
- Transient redness / swelling
- Mild fatigue
Less common
- Headache
- Dizziness
- Transient glucose changes
Precautions
- Allergic reaction / hypersensitivity
- Contraindicated in active malignancy (IGF pathway)
- Limited data in humans
As it is related to the IGF pathway (cell proliferation), there is a theoretical precaution in states of active malignancy. Scientific reference, not an instruction for use.
Related peptides
IGF-1 LR3
Complementary IGF-1 analogue
Somatropin (HGH)
Full growth hormone
CJC-1295 without DAC
GHRH analogue
Peptide Matrix Water™
Recommended reconstitution solvent
See: All peptides · Blog
Research warning: PEG-MGF is offered exclusively for scientific, research and in vitro purposes. It is not intended for human/veterinary use, diagnosis, treatment or prevention of any condition and is not medical advice. PEG-MGF is prohibited in sport (WADA).
How does it differ from IGF-1 LR3?
IGF-1 LR3 gives a prolonged, systemic anabolic action; PEG-MGF acts as a local, “initiating” signal for satellite cells. They are often studied together as complementary.
Does PEG-MGF work through the IGF-1 receptor?
The data suggest involvement of IGF-related pathways and satellite cells, but the mechanism is context-dependent . There are also publications with limited in vitro effects for certain fragments.
Buy PEG-MGF in Cyprus – price
You can buy PEG-MGF in Cyprus online from Peptology. Prices by strength:
- PEG-MGF: €40.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
PEG-MGF 2 mg: which strength
PEG-MGF is available in: 2 mg.
Research protocols
Important: Reference information for research purposes — not a recommendation for use or medical advice.
In the research literature, PEG-MGF regimens take into account the regenerative “mechanical” role and the prolonged action of the pegylated form:
- Timing after load/exercise is studied, for alignment with the natural repair response
- Thanks to pegylation, the frequency of administration is lower than that of natural MGF
- It is often studied in combination with IGF-1 LR3
The regimens come from the literature and are not a recommendation for individual use.
Storage and reconstitution
Supplied as a lyophilised powder in a 2 mg vial. Lyophilised, it is stable at room temperature, away from light/moisture. For reconstitution, the recommended solvent is Peptide Matrix Water™, which significantly extends the life of the solution.
- Before reconstitution: room temperature, away from light/moisture; up to 24 months.
- With Peptide Matrix Water™ (recommended): refrigerator 2–8 °C up to 60 days — the best stability option.
- With bacteriostatic water or sterile water: refrigerator 2–8 °C up to 28 days. No re-freezing.
- Reconstitution: add the solvent slowly down the wall, without vigorous agitation.
Laboratory tip: Add Peptide Matrix Water™ to your basket — the recommended stabilising solvent for all reconstituted peptides.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after addition (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 2 mg | 2 mg/mL | 1 mg/mL | 0.67 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
How is it stored?
The lyophilised vial is stored at room temperature, away from light. After reconstitution: with Peptide Matrix Water™ — up to 60 days at 2–8 °C; with bacteriostatic water — up to 28 days.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
PEG-MGF - 2mg - Batch - 0226 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
-
Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about PEG-MGF
Where can I buy PEG-MGF in Cyprus and what does it cost?
In Cyprus you can buy PEG-MGF online from Peptology, from €40.00. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is PEG-MGF?
It is the pegylated form of Mechano Growth Factor (MGF, IGF-1Ec), a variant of IGF-1 produced in muscle after mechanical stress. It activates satellite cells for muscle repair and regeneration.
In what form is PEG-MGF available?
As a lyophilised powder in a glass vial (2 mg). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of PEG-MGF?
The safety profile of PEG-MGF in humans is not fully characterised, as the data come mainly from preclinical studies. The reactions reported are generally mild.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.