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DSIP
DSIP 5 mg – delta sleep-inducing nonapeptide
Peptology Ltd. · Peptides for skin, sleep and libido
DSIP is a delta sleep-inducing nonapeptide that Peptology supplies strictly for laboratory research, in 5 mg. You can buy DSIP in Cyprus online from €29.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
29,00 € · In stock
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 18/10/2026
What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a natural neuropeptide of nine amino acids (nonapeptide), with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It was discovered through research into the brain factors of deep sleep (delta waves) and is one of the most studied peptides related to sleep and stress regulation.
It is a small molecule that crosses the blood-brain barrier, which makes it of interest for central nervous system research. Unlike Semax (nootropic) or Selank (anxiolytic), DSIP is oriented towards sleep and stress balance.
It is studied in research for the regulation of sleep and circadian rhythm, the modulation of stress and cortisol and neuroprotective/antinociceptive actions. See the range in the all peptides category.
In the Peptology version, it is supplied as a lyophilised powder for research use with purity > 99%, in a 5 mg format. It is intended exclusively for scientific, research and in vitro applications — it is not a medicine and is not approved for human/veterinary use.
Available form: 5 mg
5 MG
Typical form
Covers an extended research series at microgram doses.
PURITY > 99%
Batch certificate
Independent laboratory analysis per batch.
How DSIP acts — sleep and stress
The exact mechanism of DSIP is not fully clarified, but research links it with sleep, circadian rhythm and hormonal balance.
DELTA SLEEP
DSIP was linked with the delta waves of deep sleep — the restorative phase — and is studied for its role in sleep architecture.
STRESS AND CORTISOL
It is studied for the modulation of the stress response and cortisol levels, with a balancing action on the hypothalamic-pituitary-adrenal axis.
NEUROMODULATION
It crosses the blood-brain barrier and has been studied for antinociceptive (pain) and antioxidant actions.
Why DSIP is a “balance peptide”
DSIP does not act as a classic hypnotic. Research describes it rather as a regulator — a molecule that influences regulatory systems (sleep, stress, circadian rhythm) towards balance, not through forceful “sedation”. Hence the interest in sleep without the “heavy” feeling of sleeping pills.
The mechanisms come from preclinical studies and are not a guarantee of the result of a research product. The plasma half-life of DSIP is very short, although the actions studied appear to exceed it.
Properties and pharmacology
- Structure: nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu)
- Characteristic: crosses the blood-brain barrier
- Directions: delta sleep, circadian rhythm, cortisol/stress, antinociceptive action
- Profile: neuromodulator, not a classic hypnotic
- Half-life: very short (minutes), with an apparently longer action
- Status: research product, not approved for human use
DSIP vs. Selank vs. Semax — three neuropeptides
A comparison of three neuropeptides in the catalogue, with different profiles. Reference data.
| DSIP | Selank | Semax | |
|---|---|---|---|
| Main profile | Sleep / stress | Anxiolytic | Nootropic |
| Structure | Nonapeptide | Tuftsin analogue | ACTH(4-10) analogue |
| Main direction | Delta sleep, cortisol | ↑ BDNF, GABA | ↑ BDNF / NGF |
| Usual route | Subcutaneous | Intranasal | Intranasal |
| Status | Research | Research | Research (approved in Russia) |
Sources: literature on DSIP and sleep neuropeptides.
Research
Sleep and circadian rhythm
The name comes from the original link with delta sleep. Research has investigated the role of DSIP in regulating sleep architecture and circadian rhythm, with variable results.
Stress, pain and neuroprotection
Preclinical studies investigated stress-modulating (cortisol), antinociceptive (pain) and antioxidant actions, which make it a molecule of interest beyond sleep.
Data limitations
The exact mechanism and molecular target of DSIP have not been fully clarified, and extensive clinical studies in humans are lacking. That is why it is used exclusively in a research context.
Note: Scientific reference based on published data. It is not medical advice or a claim about the product.
In brief — scientific profile
- Neuromodulatory nonapeptide — sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- Linked with delta sleep — the restorative phase
- Modulates stress and cortisol — balancing, not forceful suppression
- Crosses the blood-brain barrier — action in the CNS
- Additional actions studied — antinociceptive, antioxidant
- Research product — mechanism not fully clarified
Side effects and safety
Common
- Injection-site reactions
- Drowsiness / sleep changes
- Mild headache
Less common
- Dizziness
- Daytime fatigue
- Transient mood changes
Precautions
- Allergic reaction / hypersensitivity
- Mechanism/safety not fully characterised
- Limited safety data in humans
Since the mechanism of DSIP is not fully clarified, the safety profile remains incompletely characterised. Scientific reference, not instructions for use.
Related peptides
Selank
Anxiolytic neuropeptide
Semax
Nootropic neuropeptide
Kisspeptin-10
Neuropeptide of the HPG axis
Peptide Matrix Water™
Recommended reconstitution solvent
See: All peptides · Blog
Research warning: DSIP is offered exclusively for scientific, research and in vitro purposes. It is not intended for human/veterinary use, or for the diagnosis, treatment or prevention of any condition, and is not medical advice.
How does it differ from Selank and Semax?
All are neuropeptides, with different profiles: DSIP for sleep/stress, Selank anxiolytic, Semax nootropic.
Can it be combined with melatonin?
Yes, it is often used in synergistic research, but it is important to observe the effect on the REM phase.
Molecule identity
| CAS number | 62568-57-4 |
|---|---|
| Molecular weight | 848.8 g/mol |
| Molecular formula | C35H48N10O15 |
| Class | Neuropeptide (nonapeptide) |
| Form | Lyophilised powder in a glass vial |
| Storage | Lyophilisate: 2–8 °C, dry and protected from light · after reconstitution: 2–8 °C |
Buy DSIP in Cyprus – price
You can buy DSIP in Cyprus online from Peptology. Prices by strength:
- DSIP: €29.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
DSIP 5 mg: which strength
DSIP is available in: 5 mg.
Research protocols
Important: Reference information for research purposes — not a recommendation for use or medical advice. DSIP is not approved for human/veterinary use.
In the research literature, DSIP is studied subcutaneously, at microgram doses:
- Subcutaneous administration in the evening is common in sleep-related studies
- Doses are expressed in micrograms (mcg)
- The short half-life makes the timing of administration important in sleep protocols
The schedules come from the research literature and do not constitute a recommendation for individual use.
Storage and reconstitution
Supplied as a lyophilised powder in a 5 mg vial. The lyophilised form is stable at room temperature, away from light/moisture. For reconstitution, the recommended solvent is Peptide Matrix Water™, which stabilises the peptide and significantly extends the shelf life of the solution.
- Before reconstitution: room temperature, away from light/moisture; up to 24 months.
- With Peptide Matrix Water™ (recommended): refrigerator 2–8 °C up to 60 days — the best stability option.
- With bacteriostatic water: refrigerator 2–8 °C for up to 28 days. Do not re-freeze.
- Reconstitution: add the solvent slowly down the wall, without vigorous agitation.
Laboratory tip: Add Peptide Matrix Water™ to your basket — the recommended stabilising solvent for all reconstituted peptides.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after addition (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 5 mg | 5 mg/mL | 2.5 mg/mL | 1.67 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
How is it stored?
The lyophilised vial is stored at room temperature, away from light. After reconstitution it is stored at 2–8 °C; avoid re-freezing.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
DSIP - 5mg - Batch - 0226 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
-
Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about DSIP
Where can I buy DSIP in Cyprus and what does it cost?
In Cyprus you can buy DSIP online from Peptology, from €29.00. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is DSIP?
DSIP = Delta Sleep-Inducing Peptide. The name comes from the original link with the delta waves of deep sleep.
In what form is DSIP available?
As a lyophilised powder in a glass vial (5 mg). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of DSIP?
Since the mechanism of DSIP is not fully clarified, the safety profile remains incompletely characterised. Scientific reference, not instructions for use.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.