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Cagrilintide
Cagrilintide 5/10 mg – long-acting amylin analogue
Peptology Ltd. · Peptides for weight loss
Cagrilintide is a long-acting amylin analogue that Peptology supplies strictly for laboratory research, in 5/10 mg. You can buy Cagrilintide in Cyprus online from €45.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
45,00 € · In stock
- 5mg — 45,00 €
- 10mg — 75,00 €
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 19/10/2026
What is Cagrilintide?
Cagrilintide (AM833) is a synthetic, long-acting amylin analogue — an agonist of the amylin receptors (AMY1, AMY3) and of the calcitonin receptor. The attached fatty acid residue ensures reversible binding to albumin and a long half-life (~7–8 days).
Unlike incretin agonists such as Semaglutide (GLP-1), Tirzepatide (GLP-1/GIP) or Retatrutide, Cagrilintide acts on a separate pathway — the amylin receptors in the CNS. That is why it is studied on its own and in combination with GLP-1 receptor agonists, such as semaglutide. It remains an experimental molecule; you will find the ready-made combination as CS10.
At Peptology it is supplied as a lyophilised research peptide with purity above 99% (HPLC/MS, CoA per batch), in a 5 mg pack. Exclusively for research and in vitro applications; it is not a medicine. See also the peptides for weight loss (GLP-1).
Available pack sizes: 5 mg and 10 mg
Cagrilintide is available in lyophilised 5 mg and 10 mg forms, covering the typical scales of research work — from individual in vitro runs to longer protocols, including schedules in combination with GLP-1 agonists.
5 MG
Standard pack
A lyophilised amylin analogue with purity > 99%, for studies of the amylin receptors (AMY1, AMY3) and calcitonin, on its own or together with GLP-1 agonists.
10 MG
Extended pack
Double the quantity in one vial — for longer series, higher target concentrations and fewer reconstitution cycles.
COMBINATION
CS10 (Cagrilintide + Semaglutide)
A ready-made research combination of amylin + GLP-1 in one vial — for protocols that study the additive effect of the two pathways.
The 5 mg and 10 mg packs have purity > 99% and a laboratory certificate for the corresponding batch. The choice of quantity depends on the scale of the protocol, not on the concentration of the active substance.
How it acts — agonism of the amylin receptors
Cagrilintide mimics the action of amylin by stimulating the amylin receptors in the brain — a pathway separate from the incretins (GLP-1/GIP). The three axes below summarise the main directions.
AMYLIN RECEPTORS
It activates the amylin receptors (AMY1, AMY3) — complexes of the calcitonin receptor with the proteins RAMP1/RAMP3.
SATIETY & APPETITE
It also binds to the calcitonin receptor (CTR); in research models gastric emptying is recorded as a parameter.
SYNERGY WITH GLP-1
Because the amylin pathway is separate from the GLP-1 receptor, it is also studied in combination with semaglutide.
Amylin and GLP-1 act on different receptor families (AMY/CTR and GLP-1R); that is why Cagrilintide is mainly studied together with GLP-1 agonists. The results of the studies are listed in the “Clinical studies” section.
Pharmacokinetics
- Half-life: ~7–8 days (~180 hours) — once-weekly dosing
- Long-acting mechanism: reversible binding to albumin (like semaglutide)
- CAS number: 1415456-99-3
- Class: amylin analogue, separate from the GLP-1/GIP incretins
- Phase II doses (monotherapy): 0.3–4.5 mg SC weekly
Cagrilintide vs Semaglutide vs CS10
Cagrilintide is an amylin analogue (AMY/CTR receptors), not an incretin agonist. Scientific comparison data, not a direct head-to-head comparison.
| Cagrilintide | Semaglutide | CS10 | |
|---|---|---|---|
| Mechanism | Amylin analogue | GLP-1 mono-agonist | Amylin + GLP-1 |
| Category | Amylin mimetic | Incretin | Amylin + incretin |
| CAS number | 1415456-99-3 | 910463-68-2 | 1415456-99-3 + 910463-68-2 |
| Half-life | ~7–8 days | ~7 days | ~7 days |
| Weight reduction | ~6–10.8% (phase II) | ~14.9% (STEP 1) | ~20.4% (REDEFINE 1) |
| In the Peptology catalogue | Lyophilised powder · 5/10 mg · for research only | Lyophilised powder · 5/10 mg · research only | Lyophilised powder · 5+5 mg · for research only |
Sources: Lau et al., phase II, The Lancet (2021, n=706); REDEFINE 1/2 programme (NEJM 2025). Data from different programmes, not a direct comparison or a claim about a research-grade product.
Clinical studies
In phase II (The Lancet, 2021; 706 adults, 26 weeks), cagrilintide as monotherapy (0.3–4.5 mg SC weekly) gave a mean weight reduction of 6.0–10.8% versus 3.0% with placebo. The half-life in early studies was ~180 hours.
In the phase III REDEFINE 1 (NEJM, 2025; ~3400 adults with obesity, 68 weeks), the combination of cagrilintide + semaglutide gave a mean weight reduction of 20.4%, versus 11.5% for cagrilintide alone, 14.9% for semaglutide alone and 3% for placebo; ~60% of participants achieved a reduction of ≥ 20%. The parallel REDEFINE 2 evaluated the combination in type 2 diabetes, with a significant weight reduction and improvement in glycaemic control.
The information on the clinical studies is provided for scientific and informative purposes based on published results; it is not medical advice or a claim about the research-grade product.
Documented clinical results
The results relate to published clinical studies on cagrilintide and its combination with semaglutide; they are not a promise of a result or a claim about the research-grade product.
Related peptides
CS10 (Cagrilintide + Semaglutide)
Ready-made combination of amylin + GLP-1
Semaglutide
GLP-1 mono-agonist
Tirzepatide
Dual GLP-1 / GIP agonist
Retatrutide
Triple GLP-1 / GIP / glucagon agonist
Peptide Matrix Water™
Reconstitution stabilising solution
Catalogue: Peptides for weight loss (GLP-1) · Peptide solutions · Blog
Research warning: Cagrilintide is offered exclusively for scientific, research and in vitro purposes. It is not a medicinal product, is not approved for use in humans or animals and does not replace medical advice. All the information on the clinical studies relates to cagrilintide and its combination with semaglutide and is provided for scientific and informative purposes; it is not a claim about the action of the research-grade product offered by Peptology.
How does it differ from GLP-1 agonists?
GLP-1 agonists (such as Semaglutide ) act on the incretin receptors, whereas Cagrilintide acts on the amylin receptors. It is mainly studied as a complementary partner; in combination the effect is additive.
Can it be combined with other peptides?
Yes. The recommended combination is with Semaglutide, Tirzepatide or GH 191AA.
Molecule identity
| CAS number | 1415456-99-3 |
|---|---|
| Molecular weight | 4409 g/mol |
| Molecular formula | C194H312N54O59S2 |
| Class | Long-acting amylin analogue |
| Form | Lyophilised powder in a glass vial |
| Storage | Lyophilisate: 2–8 °C, dry and protected from light · after reconstitution: 2–8 °C |
References
- Lau DCW et al. Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial. Lancet. 2021;398:2160–2172.
- Garvey WT et al. Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2025;393:635–647.
- Davies MJ et al. Cagrilintide–Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes. N Engl J Med. 2025;393:648–659.
- Wilding JPH et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384:989–1002.
Buy Cagrilintide in Cyprus – price
You can buy Cagrilintide in Cyprus online from Peptology. Prices by strength:
- 5mg: €45.00
- 10mg: €75.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
Cagrilintide 5/10 mg: which strength
Cagrilintide is available in: 5/10 mg.
Research protocols
Important: The doses relate to published clinical studies, for scientific and informative purposes — not a recommendation for use or medical advice. Research-grade Cagrilintide is not an approved medicine.
In the clinical programmes, cagrilintide was used weekly, subcutaneously, with gradual titration (phase II: 0.3–4.5 mg SC, titration up to 6 weeks; phase III REDEFINE: cagrilintide + semaglutide). Like the GLP-1 agonists (Semaglutide, Tirzepatide), it requires slow titration; you will find the ready-made combination as CS10. Part of controlled studies, not a recommendation for stand-alone use.
Storage and reconstitution
- Before reconstitution: room temperature, protected from light and moisture; refrigeration is not mandatory.
- With Peptide Matrix Water™: in the refrigerator at +2 to +8 °C for up to 60 days.
- With bacteriostatic/sterile water: in the refrigerator at +2 to +8 °C for up to 28 days; do not re-freeze.
- Reconstitution: add the solvent slowly down the wall (max. 3 mL); swirl gently, do not shake.
Tip: add Peptide Matrix Water™ — a stabilising solution for reconstituted research peptides.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after addition (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 5 mg | 5 mg/mL | 2.5 mg/mL | 1.67 mg/mL |
| 10 mg | 10 mg/mL | 5 mg/mL | 3.33 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
How is it stored and reconstituted?
The lyophilised vial at room temperature, with no need for refrigeration. After reconstitution: with Peptide Matrix Water™ up to 60 days; with bacteriostatic/sterile water up to 28 days, without re-freezing.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
Cagrilintide - 5mg - Batch - 0226 - Purity
Cagrilintide - 10mg - Batch - 0226 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
-
Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about Cagrilintide
Where can I buy Cagrilintide in Cyprus and what does it cost?
In Cyprus you can buy Cagrilintide online from Peptology, from €45.00 (5mg: €45.00, 10mg: €75.00). Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is Cagrilintide?
A synthetic, long-acting amylin analogue. It activates the amylin receptors (AMY1, AMY3) and the calcitonin receptor, via a pathway separate from the GLP-1/GIP incretins.
In what form is Cagrilintide available?
As a lyophilised powder in a glass vial (5/10 mg). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of Cagrilintide?
Peptology does not publish its own safety data for Cagrilintide; for adverse events, see the original publications of clinical and preclinical studies. The product is supplied strictly for laboratory research and is not intended for human or veterinary use.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.