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TB500
TB-500 5/10 mg – synthetic fragment of thymosin β4
Peptology Ltd. · Recovery and anabolic peptides
TB-500 (TB500, TB 500) is a synthetic fragment of thymosin β4 that Peptology supplies strictly for laboratory research, in 5/10 mg. You can buy TB-500 in Cyprus online from €20.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
20,00 € · In stock
- 5mg — 20,00 €
- 10mg — 35,00 €
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 18/10/2026
What is TB-500?
TB-500 (TB500, Thymosin Beta-4 fragment, Tβ4 fragment) is a synthetic peptide derived from the bioactive region of Thymosin Beta-4 — a natural protein of 43 amino acids, present in almost every cell and involved in tissue regeneration. TB-500 contains the key motif LKKTET, responsible for actin binding, thus concentrating the main cell-migration, angiogenesis and repair properties of the parent molecule.
Together with BPC-157, TB-500 is among the most studied peptides in the “regeneration and recovery” category. The two have complementary mechanisms — which is why they appear together in formulas such as BB20 or GLOW70.
It is studied in research for cell migration and differentiation, angiogenesis (formation of new blood vessels), repair of tissues and connective tissue, as well as anti-inflammatory actions. See the range in the all peptides category.
In the Peptology version, it is supplied as a lyophilised research-grade powder with purity > 99%, in two formats — 5 mg and 10 mg. It is intended exclusively for scientific, research and in vitro applications — it is not a medicine and is prohibited in sport (WADA).
Available formats: 5 mg and 10 mg
5 MG
Typical form
For validation experiments and protocols of usual size.
10 MG
Extended form
For longer courses and higher-consumption protocols.
Both forms have purity > 99% and a laboratory certificate for each batch. The choice depends on the scale of the protocol.
How TB-500 works — actin binding
ACTIN BINDING
Through the LKKTET motif, TB-500 binds monomeric G-actin (1:1) and regulates the G-actin ↔ F-actin balance — the basis of cytoskeleton dynamics and motility.
CELL MIGRATION
By regulating the actin cytoskeleton, it promotes the migration of cells (endothelial and progenitor) towards repair sites — a critical step of regeneration.
ANGIOGENESIS
In preclinical studies, TB-500 promotes the formation of new blood vessels (via VEGF) and has anti-inflammatory actions — supporting the oxygen supply to the tissue.
Why TB-500 and BPC-157 are “complementary”
TB-500 acts mainly on the cytoskeleton and cell migration (mobilising cells towards the target), while BPC-157 acts mainly on local angiogenesis and growth pathways. This very complementarity explains why they are often studied together.
Unlike the parent molecule (Thymosin Beta-4, 43 amino acids), TB-500 is a synthetic, smaller and more stable form, with good tissue distribution. The mechanisms come from preclinical studies and are not a guarantee of the result of a research product.
Properties and pharmacology
- Origin: synthetic fragment of Thymosin Beta-4 (a natural protein of 43 amino acids)
- Functional motif: the LKKTET sequence, the actin-binding region
- Molecular target: monomeric G-actin (1:1 binding)
- Studied actions: cell migration, angiogenesis (VEGF), repair, anti-inflammatory
- Distribution: good tissue penetration thanks to its small size and stability
- Status: research peptide, not approved; prohibited in sport (WADA)
TB-500 vs. BPC-157 vs. Thymosin Beta-4
Comparison of TB-500 with the other leading recovery peptide, BPC-157, and with the parent molecule, Thymosin Beta-4. Reference data.
| TB-500 | BPC-157 | Thymosin Beta-4 | |
|---|---|---|---|
| Structure | Synthetic Tβ4 fragment | Peptide (15 amino acids) | Protein (43 amino acids) |
| Main mechanism | Actin binding, migration | Angiogenesis, growth pathways | Actin binding (full) |
| Characteristic profile | Systemic cell motility | Local targeted repair | Multifunctional, large size |
| Use in stacks | Yes (with BPC-157) | Yes (with TB-500) | Rare (cost / size) |
| Status | Research (WADA-prohibited) | Research (WADA-prohibited) | Research |
Sources: literature on Thymosin Beta-4 and active fragments, preclinical studies of TB-500 and BPC-157.
Research
Tissue repair and cell migration
In vitro and animal studies have shown that Thymosin Beta-4 and its fragments promote the migration of endothelial cells and keratinocytes, accelerating wound healing in experimental models.
Angiogenesis and inflammation
In preclinical models, Thymosin Beta-4 promotes the formation of new vessels and regulates the inflammatory response, with investigation in cardiac, corneal and connective-tissue repair.
Data limitations
Most data come from preclinical studies; extensive clinical studies in humans confirming the efficacy and safety of TB-500 as it stands are lacking. It is also prohibited by WADA.
Note: Scientific reference based on preclinical data. It is not medical advice or a claim for the product.
In brief — scientific profile
- Synthetic fragment of Thymosin Beta-4 — contains the active motif LKKTET
- Regulates the actin cytoskeleton — promoting cell migration
- Angiogenesis and anti-inflammatory action — supporting repair (preclinical)
- Complementary to BPC-157 — the basis of regeneration stacks (BB20, GLOW70)
- Two formats — 5 mg and 10 mg for different protocol scales
- Research product — not approved; prohibited in sport (WADA)
Side effects and safety
The safety profile of TB-500 in humans is not fully characterised, as the data come mainly from preclinical studies. The reactions reported are generally mild.
Common
- Injection-site reactions
- Transient fatigue
- Mild “brain fog” sensation / lethargy
Less common
- Headache
- Transient redness
- Mild nausea
Precautions
- Allergic reaction / hypersensitivity
- Limited safety data in humans
- Theoretical precaution regarding angiogenesis (proliferation)
Because TB-500 promotes angiogenesis, there is a theoretical precaution where the formation of new vessels is not desirable. Scientific reference, not instructions for use.
Related peptides
BPC-157
Complementary repair peptide
BB20
BPC-157 10 mg + TB-500 10 mg
GLOW70
BPC-157 + GHK-Cu + TB-500
Peptide Matrix Water™
Recommended reconstitution solvent
See: All peptides · Blog
Research warning: TB-500 is offered exclusively for scientific, research and in vitro purposes. It is not intended for human/veterinary use, or for the diagnosis, treatment or prevention of any condition, and does not constitute medical advice. TB-500 is prohibited in sport (WADA).
Difference from BPC-157?
They are complementary: TB-500 acts mainly on cell migration (the actin cytoskeleton), BPC-157 on local angiogenesis. That is why they appear together in BB20 .
Can it be combined with other peptides?
Yes. It combines excellently with BPC-157 , GH peptides (such as CJC-1295), as well as GHRP peptides for a stronger regenerative effect.
Molecule identity
| CAS number | 885340-08-9 |
|---|---|
| Molecular weight | 889.0 g/mol |
| Molecular formula | C38H68N10O14 |
| Class | Thymosin beta-4 fragment |
| Form | Lyophilised powder in a glass vial |
| Storage | Lyophilisate: 2–8 °C, dry and protected from light · after reconstitution: 2–8 °C |
Buy TB-500 in Cyprus – price
You can buy TB-500 in Cyprus online from Peptology. Prices by strength:
- 5mg: €20.00
- 10mg: €35.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
TB-500 5/10 mg: which strength
TB-500 is available in: 5/10 mg.
Research protocols
Important: Reference information for research purposes — not a recommendation for use or medical advice. TB-500 is not approved for human/veterinary use.
In the research literature, TB-500 protocols usually have a “loading” phase and a “maintenance” phase:
- The loading phase generally lasts a few weeks, with more frequent administration
- The maintenance phase uses a reduced frequency, because of the prolonged tissue distribution
- Thanks to its stability and small size, TB-500 does not require daily administration in many protocols
TB-500 is often studied together with BPC-157 — a combination available ready-made in BB20. The schedules come from the research literature and do not constitute a recommendation for individual use.
Storage and reconstitution
It is supplied as a lyophilised powder in a vial (5 or 10 mg). Lyophilised, it is stable at room temperature, away from light/humidity. For reconstitution, the recommended solvent is Peptide Matrix Water™, which significantly extends the shelf life of the solution.
- Before reconstitution: room temperature, away from light/moisture; up to 24 months.
- With Peptide Matrix Water™ (recommended): refrigerator 2–8 °C up to 60 days — the best stability option.
- With bacteriostatic water or sterile water: refrigerator 2–8 °C up to 28 days. No re-freezing.
- Reconstitution: add the solvent slowly down the wall, without vigorous agitation.
Laboratory tip: Add Peptide Matrix Water™ to your basket — the recommended stabilising solvent for all reconstituted peptides.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after addition (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 5 mg | 5 mg/mL | 2.5 mg/mL | 1.67 mg/mL |
| 10 mg | 10 mg/mL | 5 mg/mL | 3.33 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
How is it stored?
The lyophilised vial is stored at room temperature, away from light. After reconstitution: with Peptide Matrix Water™ — up to 60 days at 2–8 °C; with bacteriostatic water — up to 28 days.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
TB500 - 5mg - Batch - 0226 - Purity
TB500 - 10mg - Batch - 0226 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
-
Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about TB-500
Where can I buy TB-500 in Cyprus and what does it cost?
In Cyprus you can buy TB-500 online from Peptology, from €20.00 (5mg: €20.00, 10mg: €35.00). Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is TB-500 (TB500, TB 500)?
It is a synthetic fragment of Thymosin Beta-4, a natural protein involved in regeneration. It contains the actin-binding motif LKKTET and is studied for cell migration, angiogenesis and tissue repair.
In what form is TB-500 available?
As a lyophilised powder in a glass vial (5/10 mg). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of TB-500?
The safety profile of TB-500 in humans is not fully characterised, as the data come mainly from preclinical studies. The reactions reported are generally mild.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.