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FOXO4-DRI
FOXO4-DRI 10 mg – synthetic D-amino-acid peptide
Peptology Ltd. · Peptides for energy and regeneration
FOXO4-DRI is a synthetic D-amino-acid peptide that targets the FOXO4–p53 interaction that Peptology supplies strictly for laboratory research, in 10 mg. You can buy FOXO4-DRI in Cyprus online from €129.00, with same-day dispatch for orders placed by 15:00. 99%+ purity, HPLC/MS certificate for every batch, so every vial comes with documented quality data. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker. The product is not intended for human or veterinary use.
129,00 € · In stock
For research use only / Not a medicine
| Purity | 99% |
|---|---|
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 19/10/2026
What is FOXO4-DRI?
FOXO4-DRI (D-Retro-Inverso) is a synthetic peptide of the class of senolytics — compounds studied for the selective removal of senescent (“zombie”) cells from tissues. In the catalogue the name “FOXO4” in practice means FOXO4-DRI, as it is the only commercially relevant peptide of the family.
“DRI” stands for D-Retro-Inverso — a special design in which the peptide consists of D-amino acids in reverse order. This preserves the spatial shape needed for binding to the target, but makes the molecule resistant to proteases and more stable inside the cell than an ordinary L-peptide — so that it reaches its intracellular target and remains active.
Senolytics are among the most discussed fields in ageing biology. With age, senescent cells accumulate in tissues; they stop dividing but remain metabolically active and secrete pro-inflammatory signals (the so-called SASP). FOXO4-DRI is studied as a tool for the selective elimination of these cells without harming healthy ones.
At Peptology it is supplied as a lyophilised research peptide with purity above 99% (see certificates), with a price in Cyprus and pay on delivery. Exclusively for research purposes; it is not a medicine. See also the other peptides for energy and regeneration.
How FOXO4-DRI acts — mechanism
In senescent cells, the FOXO4 protein binds and holds the tumour suppressor p53 in the nucleus, blocking programmed cell death and keeping the cells alive. FOXO4-DRI competitively disrupts the FOXO4–p53 complex, releasing p53 towards the mitochondrial pathway of apoptosis — selectively in senescent cells, without affecting healthy ones.
FOXO4–p53
The target is the FOXO4–p53 interaction, which in senescent cells holds p53 in the nucleus and blocks apoptosis.
SENOLYSIS
The released p53 moves to the mitochondria and triggers selective apoptosis of senescent cells.
DRI STABILITY
The D-retro-inverso structure provides resistance to degradation and a longer intracellular lifetime.
Selectivity towards senescent cells
The key idea is selectivity. Healthy cells do not rely on the FOXO4–p53 axis to survive, whereas senescent cells use exactly this interaction to avoid apoptosis. Thus disruption of the complex mainly affects senescent cells — “targeted apoptosis of senescent cells”.
Why the D-Retro-Inverso design matters
Ordinary peptides are degraded quickly by enzymes. The DRI modification (D-amino acids in reverse order) preserves the three-dimensional orientation required for binding, but makes the peptide resistant to proteolysis. The result is a longer intracellular half-life and a greater chance that the molecule reaches its nuclear target — a critical prerequisite for senolytic action.
What senescent (“zombie”) cells are
Cellular senescence is a state in which the cell stops dividing but does not die. It remains metabolically active and secretes a cocktail of pro-inflammatory molecules — the so-called SASP (Senescence-Associated Secretory Phenotype). With age they accumulate and are linked to chronic inflammation and deterioration of tissue function.
DIVISION ARREST
The cell loses the ability to divide but remains alive and active.
SASP SIGNALS
It secretes pro-inflammatory cytokines that affect neighbouring cells.
ACCUMULATION
Their number rises with age — a subject of study in ageing research.
Senolytics such as FOXO4-DRI are studied precisely to “clear” accumulated senescent cells, so that the effect on tissue function can be studied in preclinical models.
Properties and characteristics
- Type: senolytic peptide (D-Retro-Inverso)
- Target: the FOXO4–p53 complex in senescent cells
- Design: D-amino acids in reverse order — resistant to proteases
- Quantity: 10 mg per vial, lyophilised powder
- Purity: above 99%, with a CoA for each batch
- Status: in models it is applied intermittently (in cycles), not daily over the long term
- Application: exclusively for research (in vitro / preclinical models)
FOXO4-DRI among longevity peptides
The table compares FOXO4-DRI with other peptides studied in the context of ageing and cellular energy. Each acts through a different mechanism — FOXO4-DRI is the only true senolytic of the group.
| FOXO4-DRI | Epithalon | NAD+ | |
|---|---|---|---|
| Category | Senolytic | Telomeric peptide | Cofactor / energy |
| Mechanism | FOXO4–p53 | Telomerase | Mitochondria |
| Target | Senescent cells | Telomeres / pace | Cellular energy |
| Status | Intermittent | In cycles | Periodic |
The comparison is made by mechanism, for scientific reference; it is not a claim of comparative efficacy, as direct comparative studies are lacking.
Scientific basis and research
The foundational study — Cell, 2017
The publication by Baar et al. in Cell (2017) — “Targeted apoptosis of senescent cells restores tissue homeostasis” — is foundational for FOXO4-DRI. In aged mice they report improved physical endurance, greater coat density and improved kidney markers after administration.
Structural data — Nature Communications, 2025
More recent structural studies (2025) describe in more detail how FOXO4-DRI binds to the transactivation region of p53, clarifying the molecular mechanism of disruption of the FOXO4–p53 complex.
Other models
Subsequent research also examines FOXO4-DRI in keloid fibroblasts, chondrocytes, endothelial and brain ageing, broadening the preclinical field.
All available information comes from preclinical (animal and cell) models. There are no clinical data on safety and efficacy in humans — all claims are in a research context.
Documented research focus
- Senolytic research — selective removal of senescent cells in ageing models.
- p53 biology — study of the regulation of apoptosis and the FOXO4–p53 axis.
- Tissue homeostasis — effect of “clearing” senescent cells on tissue function.
- Longevity and biohacking — ageing markers in preclinical models.
The directions concern published preclinical studies and are not a claim of results or a recommendation for use.
Related products
Epithalon
Telomeric anti-aging peptide
NAD+
Cellular energy and mitochondria
Peptide Matrix Water™
Reconstitution solution
Catalogue: Peptides for energy and regeneration · Blog
Research warning: FOXO4-DRI is offered exclusively for research purposes and in vitro applications. It is not approved for clinical use, is not a medicine and is not intended for consumption by humans or animals. All information concerns preclinical studies and is for scientific reference only, not medical advice. Peptology bears no responsibility for unauthorised use of research peptides.
Molecule identity
| CAS number | 2460055-10-9 |
|---|---|
| Molecular weight | 5358 g/mol |
| Molecular formula | C228H388N86O64 |
| Class | D-retro-inverso peptide (FOXO4–p53) |
| Form | Lyophilised powder in a glass vial |
| Storage | Lyophilisate: 2–8 °C, dry and protected from light · after reconstitution: 2–8 °C |
References
- Baar MP et al. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell. 2017;169:132–147.
- Bourgeois B et al. The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI. Nat Commun. 2025;16:5672.
Buy FOXO4-DRI in Cyprus – price
You can buy FOXO4-DRI in Cyprus online from Peptology. Prices by strength:
- FOXO4-DRI: €129.00
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
FOXO4-DRI 10 mg: which strength
FOXO4-DRI is available in: 10 mg.
Research protocols
Important: There is no established protocol for humans. The approaches below reflect preclinical models and are provided for scientific reference only, without constituting a recommendation for use or medical advice.
- Lyophilised; reconstituted with a stabilising liquid according to the protocol.
- In models FOXO4-DRI is applied intermittently (in cycles) — a typical approach for senolytics, in which periods of administration alternate with pauses.
- The concentration is determined by the reconstitution volume and the aims of the research.
Storage and reconstitution
- Before reconstitution: lyophilised, frozen (−20 °C), away from light and moisture.
- After reconstitution: in the refrigerator at 2–8 °C; no re-freezing.
- Reconstitution: add the liquid slowly down the wall of the vial; swirl gently, do not shake.
For reconstitution we recommend Peptide Matrix Water™ — a stabilising solution for reconstituted research peptides; alternatively, bacteriostatic water.
Laboratory protocol — reconstitution, research protocols, storage
Standard protocol, applicable to all research peptides in the Peptology catalogue. For the concentration of the solution (mg/mL) per vial, use the peptide reconstitution calculator.
The 60-second protocol
1. SOLVENT
2. RECONSTITUTION
The solvent is added to the wall of the vial, without agitation, then wait 10–15 minutes.
3. CALCULATION
Calculator → concentration in mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — 3 mL maximum (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration is not mandatory) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you will need
Precision pipette
Calibrated, 100–1000 µL — for accurate measurement of the volume of solvent added to the vial.
70% alcohol pads
Two pads — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilised peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Wrong |
|---|---|
| Disinfect the stoppers and the work surface with 70% alcohol, work with gloves | Working without disinfection |
| The solvent is added slowly down the wall of the vial | Direct jet onto the powder — foaming and denaturation |
| Light swirling between the palms | Shaking — foam, on which the peptides denature |
| Wait 10–15 minutes at room temperature | Mechanical mixing or heating |
| Visual inspection: clear, without particles | Using a cloudy or coloured solution |
Calculating the concentration
⚠️ Maximum 3 mL of solvent. The standard vial does not allow a larger volume — do not exceed it during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after addition (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 10 mg | 10 mg/mL | 5 mg/mL | 3.33 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in the original packaging. Refrigeration is not mandatory.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard the remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade the structure of the peptide.
Four mistakes to avoid
1. Shaking for “faster dissolution”
Foam = denaturation. Only gentle swirling between the palms.
2. Unsuitable solvent
For the stability of the peptide structure, use only a sterile, purpose-designed solvent — Peptide Matrix Water is recommended.
3. Ignoring slight cloudiness
If it is not completely clear = the sample does not meet the criteria for work.
4. Removing it from the refrigerator “for an hour or two”
Short exposures add up and jeopardise stability.
Research status: All Peptology products are intended exclusively for laboratory use and research. They are not pharmaceutical products, have not been approved for human or veterinary use and do not replace medical advice. The protocol described is standard laboratory practice for working with lyophilised peptides.
Purity and certificate of analysis
99%+ purity, HPLC/MS certificate for every batch.
FOXO4-DRI - 10 mg - Batch - 0226 - Purity
Shipping and payment
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
🚚 Delivery information
- Orders placed by 15:00 are dispatched the same day, delivery in 5–7 working days.
- Shipping with BOX NOW, chosen at checkout. Free shipping from €50, otherwise €2.
Frequently asked questions about FOXO4-DRI
Where can I buy FOXO4-DRI in Cyprus and what does it cost?
In Cyprus you can buy FOXO4-DRI online from Peptology, from €129.00. Delivery in 5–7 working days with BOX NOW, free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.
What is FOXO4-DRI?
A compound studied for the selective elimination of senescent cells, which stop dividing but remain metabolically active and secrete pro-inflammatory signals (SASP).
In what form is FOXO4-DRI available?
As a lyophilised powder in a glass vial (10 mg). It is reconstituted in the laboratory with Peptide Matrix Water™ or bacteriostatic water; you can work out the concentration (mg/mL) with the <a href="/page/peptide-calculator">reconstitution calculator</a>.
Which side effects have been reported in clinical studies of FOXO4-DRI?
Peptology does not publish its own safety data for FOXO4-DRI; for adverse events, see the original publications of clinical and preclinical studies. The product is supplied strictly for laboratory research and is not intended for human or veterinary use.
How long does delivery take and how do I pay?
Orders placed by 15:00 on working days ship the same day and are delivered in 5–7 working days with BOX NOW. Shipping costs €2 and is free from €50; you pay on delivery – by card through the BOX NOW payment link, before you open the locker.